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慢性荨麻疹的真菌病因及治疗 被引量:6

Role of fungi in pathogenesis and antifungal treatment in chronic urticaria
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摘要 目的:探索慢性荨麻疹中的真菌病因及治疗对策。方法:应用混合真菌(点青霉、蜡叶支孢霉、烟曲霉、白色念珠菌、细链格胞)抗原测定了128例慢性荨麻疹病人血清中的特异性IgE抗体[S_IgE(MP1)],其中50例阳性随机平分2组,A组以常规抗组胺药物治疗,B组加用氟康唑150mg/wk,po,×8wk,治疗停止及停止后6~8wk评定疗效。结果:疗程结束时差异不显著,疗程结束后6~8wkA组的治愈率、显效率及积分下降率分别为4%,20%及33%;B组分别为40%,32%及65%,(P<0.01);复查S_IgE(MP1),A组复查13例无一例阴转,B组复查19例中17例阴转(89%)。结论:S_IgE(MP1)阳性的荨麻疹病人中体内真菌致敏可能为其重要的病因,应用抗真菌药物治疗具有临床实际意义。 AIM: To investigate the role of the fungi in the pathogenesis and antifungal treatment in chronic urticaria. METHODS: One hundred and twenty-eight patients with chronic urticaria were tested for the serum specific IgE antibody (S-IgE) to a mixed fungal antigen (MP1: Penicillum notatum, Cladosporium herbarium, Spergillus fumigatus, Candida albicans, Alternaria tenuis), and 50 patients (39%) were positive. These patients were treated with antihistaminics and equally divided into 2 group, group A and group B. Group B was added with fluconazole 150 mg po once 1 wk ×8 wk. RESULTS: Cure and markedly improved rates were not significantly different between the 2 groups by the end of the course, but the cure rates (4% vs 40%), total markedly improved rates (20% vs 32%) and the decreases of scores (33% vs 65%) were different (P<0.01) between the 2 groups by 6_8 wk after stopping the treatment. 13 patients in group A and 19 in group B were retested for the S_IgE(MP1) after the treatment. Group A showed all positive while Group B showed negative in 17 patients (89%). CONCLUSION: The sensitization by the fungi plays an important role in the pathogenesis of patients of chronic urticaria with positive S_IgE(MP1), and antifungal treatment is needed.
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 1998年第5期276-278,共3页 Chinese Journal of New Drugs and Clinical Remedies
关键词 荨麻疹 真菌 抗原 氟康唑 药物疗法 病因 urticaria antifungal agents fungal antigens fluconazole
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参考文献2

  • 1徐亚伟,上海第二医科大学学报,1994年,14卷,增刊,118页
  • 2虞瑞尧,新药与临床,1992年,11卷,245页

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