透明质酸膝骨关节腔内注射治疗膝骨关节炎

Intra-articular injection of hyaluronic acid in treating knee osteoarthritis

目的：研究透明质酸膝骨关节腔内注射治疗膝骨关节炎的疗效。方法：９０例膝骨关节炎病人，男性３８例，女性５２例，年龄６５±ｓ８ａ，随机分为Ａ，Ｂ，Ｃ３组，每组３０例，分别采用透明质酸关节腔内注射，２．５ｍＬ，ｑｗ×３ｗｋ；双氯芬酸５０ｍｇ，ｐｏ，ｂｉｄ×３ｗｋ；关节腔内注射曲安奈德注射液２０ｍｇ＋０．５％布比卡因注射液５ｍＬ＋０．９％氯化钠注射液至２０ｍＬ，ｑｗ×３ｗｋ。结果：Ａ，Ｂ，Ｃ３组有效率分别为９７％，８７％和９０％。Ｂ，Ｃ２组与Ａ组比较，差别有显著意义（Ｐ＜０．０５）。３组副作用均轻微。结论：透明质酸关节腔内注射是治疗膝骨关节炎较为有效的方法。

AIM: To study the effect of intra-articular injection of hyaluronic acid in treating knee osteoarthritis. METHODS: Ninety patients (M 38, F 52; age 65±s 8 a). with knee osteoarthritis were randomly divided into 3 groups, 30 patients in each group. Group A received hyaluronic acid 2.5 mL intra-articular injection, qw×3 wk; group B received diclofenac tablets 50 mg, po, bid for 3 wk; and group C received steroid preparation (triamcinolone acetonide injection 20 mg+0.5% bupivacaine injection 5 mL+0.9% sodium chloride 20 mL) intra-articular injection, qw for 3 wk. RESULTS: The total efficacy in group A (97%) was higher than those in group B(87%) and group C(90%), (P<0.05). The adverse reactions in 3 groups were mild. CONCLUSION: Intra-articular injection of hyaluronic acid is an effective method for knee osteoarthritis.