Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats

Intracerebroventricularly injected L-arginineinduced vasopressin release is mediated by cGMP in rats1

探讨ｃＧＭＰ是否介导Ｌ精氨酸（一氧化氮合酶底物）引起的血管加压素（ＡＶＰ）释放增多效应．方法：用放射免疫法测定大鼠血浆中ＡＶＰ水平．结果：侧脑室分别注射Ｌ精氨酸和８溴ｃＧＭＰ（一种可透过膜的ｃＧＭＰ衍生物）能刺激血浆ＡＶＰ水平增加［分别从（３２±０５）升至（５８±１４）ｎｇ·Ｌ－１，从（２６±０３）升至（６６±０４）ｎｇ·Ｌ－１，Ｐ＜００１］，同时注射Ｌ精氨酸和亚甲蓝（鸟苷酸环化酶抑制剂）对血浆ＡＶＰ的水平没有影响．