血清CK19-2G2、CYFRA 21-1和CA-125联合检测在肺癌诊断中的应用

Value of serum CK19-2G2,CYFRA 21-1 and CA-125 detecting in lung cancer diagnosis

目的探讨血清CK19-2G2、CYFRA 21-1、CA-125联合检测对肺癌的诊断价值。方法采用放射免疫法检测了110例肺癌患者、70例肺部良性疾病患者及30例健康体检者的血清CK19-2G2、CYFRA 21-1和CA-125。结果肺癌组血清CK19-2G2、CYFRA 21-1和CA-125水平及阳性检出率显著高于正常对照组和肺部良性疾病组(P均<0.01)。CK19-2G2、CYFRA 21-1在肺鳞癌中呈高表达,CA-125在肺腺癌中呈高表达。三者联合检测肺癌的灵敏度为84.5%,特异性为77%。结论血清CK19-2G2、CYFRA 21-1、CA-125水平在肺癌的诊断中有应用价值。三者联合检测诊断肺癌灵敏度高。

Objective To evaluate the value of serum CK19-2G2,CYFRA 21-1 and CA-125 detecting in diagnosis of lung cancer. Methods The serum concentration of CK19-2G2, CYFRA 21-1 and CA-125 was detected in 110 patients with lung caneer,70 with benigal lung diseases and 30 healthy volunteers. Results The serum CK19-2G2,CYFRA 21-1 and CA-125 in patients with lung eaneer were significantly higher than those in group with benign lung diseases and the control; Patients with squamous cell carcinoma of lung had a higher CK19-2G2 and CYFRA 21-1 level, while patients with adenocarnoa had a higher CA-125 level The sensitivity and specificity of tile combined determination containing the three tumor markers were 84.5% and 77% respectively. Conclusion CK19-2G2,CYFRA 21-1 and CA-125 combination detecting is valueful for the diagnosis of lung cancer.