大鼠脊髓蛛网膜下腔注射去氧肾上腺素的升压效应

Pressor response induced by spinal intrathecal injection of phenylephrine in the rat

目的为阐明脊髓内的α肾上腺素能受体对心血管活动调节的作用。方法在完整和颈1横断脊髓的大鼠，脊髓蛛网膜下腔注射（ith）选择性α1受体激动剂去氧肾上腺素后对血压和心率进行观察记录。结果①完整大鼠ith去氧肾上腺素引起血压和心率明显升高。②在颈1横断脊髓的大鼠，ith相同剂量的去氧肾上腺素也引起显著的升高血压效应。③在颈1横断脊髓的大鼠，ithα受体阻断剂妥拉苏林可减弱ith去氧肾上腺素的升压效应；用选择性α1受体阻断剂哌唑嗪预处理能阻断这种升压效应。结论在脊髓水平存在有由α1受体调控的升压机制。

To investigation the role of spinal α-adrinoceptor in the control of blood pressure.Methods In urethane anesthetized rats and C1 transected rats,the changes of mean arterial pressure and heartrate were recorded after spinal intrathecol administration of phenylephrine. Results ①Intrathecal injection ofphenylephrine produced a markede pressor response and an increase in heart rate. ② The same dose ofphenylepheine also caused an increase in mean arierial blood pressure in Cl transected rats ③ this PressorresPonse were attenuated singnilicanily by a α - adrnoceptor blocker, and prazosin, a α1 - adrenoceptorblocker. ConcluSbo The α1-adrnoceptor in spinal cord play an important role in mediating thecardiovasclilar Pressor effect.