阻塞性睡眠呼吸暂停低通气综合征合并高血压患者夜间血压变化分析

Study of fluctuation of blood pressure at night about the patients of obstructive sleep apnea syndrome complicated with hypertension

目的通过对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压患者夜间血压变化情况的研究,进一步探讨OSAHS与高血压的相关关系。方法选取确诊的OSAHS合并高血压患者95例,所有患者记录一般情况包括体质指数、颈围/身高的比值、就诊时血压,完成至少7小时的多导睡眠监测(PSG),同时测量患者的睡前血压,夜间血压,醒后即刻血压,将其与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)不合并高血压患者进行比较分析。结果两组患者的体质指数和颈围/身高的比例无统计学差异。在研究中,不同严重程度的OSAHS患者的最高血压高低无统计学差异。AHI与醒时即刻-睡着SBP差值,睡着-睡前DBP差值无统计学相关性(P>0.05),与睡着-睡前SBP差值及醒时即刻-睡着DBP差值有相关性(P<0.05)。结论OSAHS组及OSAHS合并高血压组患者夜间收缩压(SBP)虽有一定程度的下降,但是两组均只有3%～4%左右,睡着-睡前舒张压及醒时即刻-睡着血压的变化与AHI相关(P<0.05)。

【Objective】To study the correlation between OSAHS with hypertension by research fluctuation of blood pressure at night about the patients of obstructive sleep apnea syndrome （OSAHS） complicated with hypertension.【Methods】We chose 95 patients who diagnosted OSAHS complicated with hypertension and research the correlation.All patients had been monitored at least for 7 hours in the lab.And the indexes included blood pressure during sleeping and arousal,apnea hypopnea index,the lowest blood oxygen saturation,the total time of oxygen saturation lower than 90%,body mass index,c-circumstance/height ratio,et al.【Results】 The body mass index,ccircumstan/height ratio had no significant beween different group （P 〉0.05）.T here were no significance of the highest hypertension between the different severe degree OSAHS patients.There is no correlation between AHI with the difference value of SBP before sleeping and sleeping,DBP arousal and sleeping （P 〉0.05）,but there are correlation between AHI with the difference value of DBP before sleeping and sleeping,SBP arousal and sleeping （P 〈0.05）.【Conclusion】The systolic blood pressure of OSAHS group and OSAHS with hypertension group only had 3-4% decreased during the night.There are correlation between AHI with the difference value of DBP before sleeping and sleeping,arousal and sleeping （P 〈0.05）.