清肝解毒注射液治疗大鼠实验性急性肝衰竭的研究

Injection for Removing Heat and Toxin from Liver Used in Treatment of Experimental Acute Liver Failure in Rats

目的：研究清肝解毒注射液治疗大鼠急性肝衰竭（ＦＨＦ）的作用。方法：用Ｄ氨基半乳糖（Ｇａｌｎ）造成大鼠实验性ＦＨＦ，观察清肝解毒注射液对其存活率和肝功能的影响，并设肝细胞生长因子（ＨＧＦ）为对照。结果：清肝解毒注射液组（简称清肝组）大鼠存活率为６３．６４％，ＨＧＦ组和模型组分别为５９．０９％和２７．２７％，清肝组存活率明显高于模型组，Ｐ＜０．０５。该药还可降低ＦＨＦ大鼠ＡＬＴ、ＴＢｉｌ水平，提高ＴＣＨ活性，与模型组比较差异显著。

Objective:To investigate into the effect of the injection on rats'liver failure.Method:D-galactosamine was used to cause experimental acute liver failure in rats so as to observe the effect of the injection on the survival rate and liver function,compared with hepatic growth factor(HGF).Result:In the treatment group,the rat survival rate was 63.64% while in the HGF group and model group,this figure was 59.09% and 27.27% respectively, P<0.05 .This injection could also reduce ALT and T-Bil levels,and increase TCH activity,with marked difference from the model group.Conclusion:This injection has marked antagonizing effect on experimental acute liver failure induced by D-galactosamine.