动态监测降钙素原对肝移植患者感染及预后判断的意义

Clinical Significance of Dynamic Determination of Serum Procalcitonin Levels in Judgement of Infection and Prognosis in Patients with Liver Transplantation

目的:探讨动态监测降钙素原(PCT)对肝移植患者感染及预后判断的临床意义。方法:对33例肝移植患者在术后第1、3、5、7天分别采集静脉血标本检测血清PCT值,并同时测定C反应蛋白(CRP)和白细胞(WBC)计数,以判断PCT水平变化与肝移植感染及预后之间的关系。结果:肝移植组术后第1天的血清PCT水平显著高于对照组(P<0.05),而血清CRP水平、WBC计数与对照组比较差异无显著性(P>0.05);合并感染组与非感染组相比各时段血清PCT明显升高,差异有显著性(P<0.05)。结论:PCT水平可以有效判断肝移植术后感染的严重程度;PCT的动态变化能有效预测肝移植患者预后。

Objective：To explore the clinical significance of dynamic determination of serum procalcionin（PCT） levels in judgement of infection and prognosis in patients with liver transplantation.Methods：Serum PCT levels were detected in 33 patients with liver transplantation on the first,third,fifth,and seventh day,and C-reactive protein（CRP）and white blood cell（WBC）count were detected at the same time.The association of the changes of PCT and infection in the patients and their prognosis was analyzed.Results：Serum PCT level at the first day of liver transplantation group was significant higher than the control group（P0.05）,while serum CRP levels,WBC counts had no significant difference（P0.05）.Serum PCT levels in the concurrent infection were significant higher than those in the non-infection group at different time points（P0.05）.Conclusion：The alteration of serum PCT level may be used as one of the effective predictors for infection in patients with liver transplantation and for their prognosis.