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泛素样蛋白ISG15在抗病毒天然免疫中的作用 被引量：7

The Role of the Ubiquitin Like Protein ISG15 Coded by Interferon Stimulated Gene 15 in the Antiviral Innate Immune Response
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摘要 干扰素刺激基因15(ISG15)编码的蛋白是抗病毒天然免疫通路中的重要调节因子,病毒感染和干扰素刺激均可强烈诱导ISG15的表达。ISG15是最早发现的泛素样蛋白,可对细胞内多种蛋白进行修饰并调节蛋白功能,但不介导蛋白质的降解,在机体抗病毒天然免疫反应中发挥重要作用,其机制尚未完全明确。近几年对ISG15的研究有所突破,发现了ISG15在抗病毒天然免疫反应中的新功能。我们简要概述了泛素样蛋白ISG15的概况、修饰酶系统及ISG15在抗病毒天然免疫反应中功能的研究进展。 ISG15 protein coded by interferon stimulated gene 15（ISG15）is a crucial ragulater of the interferon signaling pathways.The expression of ISG15 could be strongly induced by typeⅠinterferons.ISG15 is the first ubiquitin-like modifier to be identified.ISGylation does not drive protein degradation,but rather parallels ubiquitin＇s activating effects and plays an important role in the innate antiviral response although the detail mechanism was still unknown yet.Recently,new functions of the ISG15 in innate antiviral response have been discovered.This review provided an overview of ISG15 and its fuctions in antiviral innate immune pesponse.
作者 胡日查 杨宇东 孙莉 邢雅玲 陈晓娟 张七斤 陈忠斌
机构地区 内蒙古农业大学动物科学与医学学院 军事医学科学院放射与辐射医学研究所感染与免疫学实验室
出处 《生物技术通讯》 CAS 2010年第1期94-97,135,共5页 Letters in Biotechnology
基金 国家自然科学基金(30870536 30671843) 科技部重大专项课题(2008ZX10004-015) 北京市自然科学基金(7092075)
关键词 干扰素刺激基因15 泛素样蛋白 抗病毒天然免疫 干扰素调节 interferon stimulated gene 15 ubiquitin like protein antiviral innate immunity interferon regulation
分类号 Q71 [生物学—分子生物学]
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参考文献20

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二级参考文献33

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生物技术通讯
2010年 第1期

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