硫酸软骨素和硫酸氨基葡萄糖对成人大骨节病的疗效分析

Analysis of curative effect of chondroitin sulfate and glucosamine sulfate on Kaschin-Beck disease

目的观察硫酸软骨素和硫酸氨基葡萄糖对大骨节病的疗效。方法2007年7月，在黑龙江省尚志市光辉村按《大骨节病诊断标准》检出患者80例。按病情等级、年龄、性别将80例患者分成治疗组、对照组，每组40人。治疗组给予硫酸软骨素和硫酸氨基葡萄糖治疗，对照组给予安慰剂（等量淀粉）。在治疗前及治疗后（第8个月）对患者进行直立体位的膝关节X线拍片，利用刻度放大镜测量X线膝关节腔宽度。结果对照组治疗前、后的X线膝关节腔宽度分别为（4．30±2．14）、（4．10±2．07）mm，治疗组分别为（4．17±2．15）、（4．16±2．11）mm。药物对X线关节腔宽度没有影响（F=0．50，P〉0．05），时间、药物与时间的交互作用对X线关节腔宽度有影响（F值分别为67．66、46．74，P均〈0．05）。治疗组X线关节腔宽度治疗前低于对照组（P〈0．05），治疗后高于对照组（P〈0．05）；对照组治疗前X线关节腔宽度高于治疗后（P〈0．05）。结论硫酸软骨素和硫酸氨基葡萄糖减缓了成人大骨节病患者膝关节间隙继续变窄的进程，对关节软骨起到了保护作用，为成人大骨节病治疗在药物选择和疗效判定上提供了依据。

Objective To research the curative effect of chondroitin sulfate and glucosamine on Kashin- Beck disease （KBD）. Methods According to Diagnosis for Kashin-Beck disease, 80 patients of adult KBD were detected from Guanghui village Shangzhi city Heilongjiang province in July, 2007, and they divided into treatment group and control group according to their condition, age and sex, 40 person in each group. Treatment group was given chondmitin sulfate and glucosamine sulfate, and control group was given placebo（equivalent amount of starch）. Bilateral knees X-ray films were shot before and after treatment（8th month）, scale division magnifying glass was used to measure the width of joint space on X-ray films. Results The width of joint space respectively was （4.30 ± 2.14） and （4.10_± 2.07）ram in control group before and after treatment, and treatment group respectively was（4.17 ± 2.15）, （4.16 ± 2.11）ram. Medicine had no obviously role on joint space（F = 0.50, P 〉 0.05）, Time and both of time and medicine had obvious role on joint space（F = 67.66,46.74, all P 〈 0.05）. Joint space of treat group was thinner than control group（P 〈 0.05） before treatment, but thicker after treatment（P 〈 0.05）. To compare with the width of before treatment, joint space width of control group became obviously narrow（P〈 0.05）. Conclusions Experimental group taking chondroitin sulfate and glucosamine sulfate alleviated knee joint space narrowing process of adults KBD patients compared with control group. It plays a protection role in articular cartilage and provides evidences for choosing drug and evaluating effect in the treatment of adults KBD.