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抑制基因组转座子活性的小RNAs在生育调节中的作用 被引量：2

Regulation of fertility by the small RNA pathway that defends the genome against tansposons
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摘要 小RNAs可以在转录和转录后水平沉默转座子,最近发现的几类小RNAs(piRNAs、endo-siRNAs)均具有抑制转座子活性的作用,其中,果蝇piRNAs、小鼠piRNAs、小鼠endo-siRNAs及其相关蛋白主要在生殖系表达,说明小RNAs作用途径在生殖系转座子沉默中扮演着重要角色。最新的研究揭示了小RNAs、转座子沉默、生殖生育调节之间的联系,然而其具体作用机制尚未得到阐明。文章综述了小RNAs对基因组转座子活性的控制及其在生育调节中的作用。 Small RNAs can silence transposons at transcriptional or post-transcriptional level. Newly identified small RNAs （e.g., piRNAs and endo-siRNAs） can repress the activity of transposons. Drosophila piRNAs, mouse piRNAs, mouse endo-siRNAs, and their related proteins are expressed primarily within the germline. This suggests that the small RNA pathway plays an important role in transposon silencing of the germline. Recent studies revealed the connection between small RNAs, transposon silencing, and the regulation of fertility, but the mechanism has not been clarified in detail. In this review, the advances in the control of genomic transposon activity and the regulation of fertility by the small RNA pathway were summarized and discussed.
作者 石敏 唐爱发 蔡志明
机构地区 北京大学深圳医院男性生殖与遗传广东省重点实验室
出处 《遗传》 CAS CSCD 北大核心 2010年第1期11-16,共6页 Hereditas（Beijing)
基金 "985工程"资助子项目(编号:985-2-054-29) 国家自然科学基金项目(编号:30700824) 广东省医学科研基金项目(编号:A2008634) 973计划前期研究专项课题
关键词 小RNAs 生殖系 转座子沉默 small RNAs germline transposon silencing
分类号 Q78 [生物学—分子生物学]
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参考文献32

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同被引文献58

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