皮卡佐剂和皮卡狂犬病疫苗的安全性

Safeties of PICKCa as An Adjuvant and Rabies Vaccine Using The Adjuvant

皮卡(PICKCa)即聚肌胞注射液,是一种安全、有效的干扰素诱生剂。以皮卡为佐剂制成的皮卡狂犬病疫苗,其安全性不仅符合《中国药典》要求,而且其毒性、抗原含量和防腐剂含量均低于现行人用狂犬病疫苗。本文就皮卡佐剂及皮卡狂犬病疫苗的安全性作一综述。

As a conjugate of poly I,poly C,kanamycin（K）and calcium chloride（Ca）,PICKCa is a safe and effective interferon inducer.The safety of rabies vaccine prepared using PICKCa as an adjuvant met the requirements in Chinese Pharmacopoeia,and its toxicity as well as antigen and preservative contents were lower than those of the current rabies vaccine for human use.The safeties of PICKCa as an adjuvant and rabies vaccine using the said adjuvant are reviewed in this paper.