rhIL-6对辐射小鼠的保护及其对血小板损伤作用的拮抗效应

Recombinant human interleukin 6 protects mice from lethal irradiation and has effects on platelets.

目的研究国产ｒｈＩＬ－６对造血系统的作用及其抗辐射效应。方法选用Ｃ５７ＢＬ／６小鼠，分别腹腔注射生理盐水（ＨＢＳＳ）或ｒｈＩＬ－６，然后致死全身照射或先致死全身照射后腹腔注射ＨＢＳＳ或ｒｈＩＬ－６。结果ｒｈＩＬ－６在辐射后对小鼠具有治疗效果，平均生存期由９．３天延长至１２．７天，对ＲＢＣ、ＨＧＢ、ＨＣＴ、ＰＬＴ均有明显的促再生作用，ｒｈＩＬ－６预防注射亦可拮抗辐射的致死效应，平均生存期由９．３天延长至１１．５天。结论ｒｈＩＬ－６在体内具有促进血细胞再生作用，从而延缓致死辐射所致死亡。

bjective To study the effects of rhIL 6 on platelets and its possible utilization in irradiation induced myelosuppression.Methods The rhIL 6 (5μg/day ×7 days) was injected into lethally irradiated C57BL/6 mice before or after irradiation.Results The survival was significantly prolonged by rhIL 6 administration either before or after irradiation when compared with HBSS group (P<001).The mean survival period prolonged from 9.3 days to 12.7 days(rhIL 6 administration after irradiation) or to 115 days (rhIL 6 administration before irradiation).rhIL 6 enhanced the contents of RBC,HGB,HCT and PLT.Conclusion The research indicates that rhIL 6 may improve platelets and be a possibly potential candidate for the treatment of irradiation induced myelosupression in clinic.