培哚普利对老年高血压病患者血浆内皮素、一氧化氮的作用

Influence of Antihypertensive Effect of Perindopril on Plasma-Endothelin and Nitric Oxide in Elderly Essential Hypertension

为了解培哚普利（Ｐｅｒｉｎｄｏｐｒｉｌ）降压治疗对内皮素（ＥＴ）和一氧化氮（ＮＯ）的影响，测定２４例老年高血压病人治疗前后血浆ＥＴ和ＮＯ稳定代谢产物ＮＯ－２／ＮＯ－３（ＮＯ－ｘ）水平。结果显示：治疗８周后血浆ＥＴ水平从（７４．０５±１１．０９）×１０－９ｇ／Ｌ降至（６２．０９±１２．５１）×１０－９ｇ／Ｌ（Ｐ＜０．０５）；ＥＴ／ＮＯ－ｘ比值从（１．２１±０．３８）明显下降至（０．７２±０．１８）ｇ／Ｌ（Ｐ＜０．０５）；而ＮＯ－ｘ水平明显升高，从（６９．９０±２４．４５）μｍｏｌ／Ｌ升至（９７．５９±２０．５５）μｍｏｌ／Ｌ（Ｐ＜０．０５）。

To investigate the influence of antihypertensive effect of perindopril on plasma endothelin(ET) and nitric oxide(NO), plasma were measured metabolites of ET and NO, products NO_2^-/NO_3^-(NO_x^-), in 24 elderly essential hypertension patients. The results showed that after 8 weeks of perindopril treatment, there were significant decreases in ET(74.05±11.09×10-9 g/L to 6209±1251×10-9 g/L, P<005) and ET/NO-x ratio(121±038 to 072±018, P<005) At the same time, NO-x increased significantly (6990±2445 μmol/L to 9759±2055 μmol/L, P<005). These findings suggest that the antihypertensive effect of perindopril may partly attribute to changes in concentrations of ET and NO.