摘要
单核苷酸多态性(single nucleotide polymorphisms,SNP)是第3代分子遗传标志,SNP决定基因的功能单位和人群遗传变异的内在特征。它反映了个体表型、疾病易感性和对药物、环境因子反应的差异。血液肿瘤是一种多基因遗传病,涉及到多个遗传易感基因的作用。本文就近年来单核苷酸多态性与其在血液肿瘤研究领域(致癌物质代谢酶基因的SNP、DNA修复基因的SNP、癌基因与抑癌基因的SNP、药物代谢相关酶基因的SNP等)的相关进展作一综述。
Single nucleotidc polymorphisms (SNPs) are the 3rd generation of molecular genetic markers of humam populations. SNPs determine the functional units of genes and the inherent characteristics of genetic variation, and reflect the individual phenotype, disease susceptibility and differences of response to drug and environmental factors. Hematological malignancy is a multi-gene genetic diseases, and involve in the role of multigenetic susceptible genes. This review intends to introduce the single nucleotide polymorphisms and their relevant progress of research on hematologic malignancies, including the SNP of carcinogen-metabolizing enzymes genes, the SNP of DNA repair genes, the SNP of oncogenes and anti-oncogene genes, the SNP of drug-metabolizing enzyme genes and so on.
出处
《中国实验血液学杂志》
CAS
CSCD
2010年第1期250-254,共5页
Journal of Experimental Hematology
基金
863计划(编号2007AA022007)
关键词
单核苷酸多态性
血液肿瘤
遗传标志
single nucleotide polymorphism
hematological malignancy
genetic marker