E钙黏着素与波形蛋白在膀胱癌中的表达及意义

The expression and significance of E-cadherin and Vimentin in transitional cell carcinoma of the bladder

目的检测E钙黏着素(E-cadherin)和波形蛋白(Vimentin)在膀胱癌组织中表达及意义。方法采用免疫组织化学技术检测60例膀胱移行细胞癌组织中E-cadherin和Vimentin的表达,分析二者的相关性及其与膀胱癌病理分级的关系。结果E-cadherin和Vimentin在不同病理分级的膀胱癌组织中的表达差异有统计学意义(P<0.01),E-cadherin异常表达与Vimentin阳性表达成正相关(r=0.330,P<0.05)。结论初步证实在膀胱癌的发生、发展中可能存在上皮间质转化(EMT)现象;联合检测E-cadherin及Vimentin对判断膀胱癌患者的预后具有一定的临床价值。

Objective To detect the expression of E-cadherin and Vimentin and to discuss their significance for prognosis. Methods The expression of E-cadherin and Vimentin in 60 specimens of transitional cell carcinoma of the bladder was detected by SP immunohistochemistry. Results The expressions of both E-cadherin and Vimentin in three differentiated grades of transitional cell carcinoma of the bladder were statistically significant （both P 〈0. 01）. There was a positive correlation between the abnormal expression of E-cadherin and the positive expression of Vimentin （r = 0. 330, P〈0.05）.Conclusions This research indicated that there is epithelial-mesenchymal transition in the development of transitional cell carcinoma of bladder. The examination of both E-cadherin and Vimentin may be useful for the prognosis of bladder carcinoma.