摘要
Transcription factor NF-κB has attracted attention due to its important role in the regulation of the expression of a number of cellular genes involved in host defense,inflammation/immune responses,cytokine and growth factor regulation,cell survival,proliferation,and also in embryonic development and programmed cell death. In this review,we provide an overview of established TNF-α,TLR/IL-1R,TCR and BCR signaling pathways to NF-κB,the alternative NF-κB pathway,and the regulation of NF-κB transcriptional activity. Furthermore,we discuss on emphasis the cross-talks between NF-κB and other signaling pathways (TGF-β,p53,nuclear receptor family,Ras/MEK/MAPK...),which are very complex and remain to be understood. The activation or inhibition of NF-κB has effect on other signaling pathways. They compose a complex signaling network,in which many regulatory signals integrate systematically and coordinate transcriptional responses to the stimulations. So when NF-κB is used as an important target of drugs in human diseases,the pathological and physiological functions of related signal pathways also should be understood sufficiently.
Transcription factor NF -κB has attracted attention due to its important role in the regulation of the expression of a number of cellular genes involved in host defense, inflammation/immune responses, cytokine and growth factor regulation, cell survival, proliferation, and also in embryonic development and programmed cell death. In this review, we provide an overview of established TNF -α, TLR/IL - 1 R, TCR and BCR signaling pathways to NF -κB, the alternative NF -κB pathway, and the regulation of NF -κB transcriptional activity. Furthermore, we discuss on emphasis the cross - talks between NF -κB and other signaling pathways (TGF - β, p53, nuclear receptor family, Ras/MEK/ MAPK... ), which are very complex and remain to be understood. The activation or inhibition of NF -κB has effect on other signaling pathways. They compose a complex signaling network, in which many regulatory signals integrate systematically and coordinate transcriptional responses to the stimulations. So when NF -κB is used as an important target of drugs in human diseases, the pathological and physiological functions of related signal pathways also should be understood sufficiently.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第1期181-187,共7页
Chinese Journal of Pathophysiology
基金
国家高技术研究发展计划(863计划)资助项目(No.2007AA091603)
关键词
NF—κB
信号通路
NF - kappa B
Signaling pathway