期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PPAR-γ配体与炎症、心肌缺血/再灌注损伤防治的研究进展 被引量：4

Advances in prevention and treatment on inflammation and myocardial ischemia-reperfusion injury by PPAR-γ ligands
下载PDF
导出
摘要 Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR-γ ligands significantly improve myocardial functional recovery and prevent ischemia-reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR-γ ligands,we know today that the therapeutic effects of PPAR-γ ligands reach far beyond their use as insulin-sensitizers,as many of these agents exert beneficial effects in the conditions associated with ischemia-reperfusion and inflammation. Peroxisome proliferation - activated receptor -γ （ PPAR -γ） is a ligand - activated transcription factor belonging to the nuelear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR -γ, ligands significantly improve myocardial functional recovery and prevent ischemia - reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR -γ ligands, we know today that the therapeutic effects of PPAR -γ ligands reach far beyond their use as insulin - sensitizers, as many of these agents exert beneficial effects in the conditions associated with isehemia - reperfusion and inflammation,
作者 刘静维 修瑞娟
机构地区 中国协和医科大学微循环研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第1期197-199,208,共4页 Chinese Journal of Pathophysiology
关键词 过氧化物酶体增殖剂活化受体γ 炎症 心肌缺血 再灌注 Peroxisome proliferator - activated receptor - γ Inflammation Myocardial ischemia Reperfusion
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献26

  • 1Guan Y, Zhang Y, Breyer MD. The role of PPARs in the transcriptional control of cellular processes [ J ]. Drug News Perspect, 2002, 15(3) : 147 - 154.
  • 2Bishop - Bailey D. Peroxisome proliferator - activated receptors in the cardiovascular system[ J ]. Br J Pharmacol, 2000, 129(5): 823-834.
  • 3Gurnell M. PPAR gamma and metabolism: insights from the study of human genetic variants [ J ]. Clin Endocrinol ( Oxf), 2003, 59 (3) : 267 - 277.
  • 4Desvergne B, Wahli W. Peroxisome proliferator- activated receptors: nuclear control of metabolism [ J ]. Endocr Rev, 1999, 20(5) : 649 -688.
  • 5Vamecq J, Latruffe N. Medical significance of peroxisome proliferator- activated receptors [ J]. Lancet, 1999, 354 (9173) : 141 - 148.
  • 6Jiang C, Ting AT, Seed B. PPAR -gamma agonists inhibit production of monocyte inflammatory cytokines [ J ]. Nature, 1998, 391(6662) : 82 -86.
  • 7Ricote M, Li AC, Willson TM, et al. The peroxisome proliferator - activated receptor - gamma is a negative regulator of macrophage activation [ J ]. Nature, 1998, 391 (6662) : 79 - 82.
  • 8Colville - Nash PR, Qureshi SS, Willis D, et al. Inhibition of inducible nitric oxide synthase by peroxisome proliferator - activated receptor agonists : correlation with induction of heme oxygenase 1 [ J]. J Immunol, 1998, 161 (2) : 978 - 984.
  • 9Wang TD, Chen WJ, Lin JW, et al. Effects of rosiglitazone on endothelial function, C - reactive protein, and components of the metabolic syndrome in nondiabetic patients with the metabolic syndrome [ J]. Am J Cardiol, 2004, 93 (3) : 362 - 365.
  • 10Marx N, Froehlich J, Siam L, et al. Antidiabetic PPAR gamma - activator rosiglitazone reduces MMP - 9 serum levels in type 2 diabetic patients with coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2003, 23(2): 283- 288.

二级参考文献8

  • 1李向青,马丽英,王孝铭,付国辉,徐长庆,马立新,王鑫.缺血再灌注时大鼠心肌局部血管紧张素Ⅱ的变化及其与能量代谢的关系[J].中国病理生理杂志,1996,12(3):263-266. 被引量：8
  • 2Lehmann JN, Moore LB, Smith Oliver TA, et al. An antidiabetic thiazolidinedione is a high atlqnity ligand for peroxisome proliferator activated receptor gamma[J]. J Biol Chem, 1995,270(22) : 12953 - 12956.
  • 3Yue TL, Chen J, Bao WK, et al. In vivo myocardial protection from isehemia/reperfusion injury by the peroxisome proliferator- activated receptor- [ gamma] agonist rosiglitazone[J]. Circulation, 2001, 104(21): 2588 - 2594.
  • 4Wayman NS, Hattori Y, Mcdonald MC, et al. Ligands of the peroxisome proliferator- activated receptors reduce myocardial infarct size[J]. FASEB J, 2002, 16(9) : 1027 - 1040.
  • 5Khandoudi N, Delerive P, Berrebi B, et al. Rosiglitazone, a peroxisome proliferator - activated receptor - gamma, inhibitsthe Jun NH(2) - terminal kinase/activating protein 1 pathway and protects the heart from ischemiafreperfusion injury[J].Diabetes, 2002, 51(5): 1507- 1514.
  • 6Zhu P, Ial L, Xu Y, et al. Troglitazone improves recovery of left ventricular function after regional ischemia in pigs [ J].Circulation, 2000, 101(10): 1165-1171.
  • 7Grazia MM, Fesc F, Pietro A, et al. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction[J]. Am Heart J,2001, 141(1): 41-46.
  • 8陈良万,郭加强.缺血再灌注损伤对心肌表达外源性基因能力的影响[J].中国病理生理杂志,2001,17(12):1254-1255. 被引量：3

共引文献12

同被引文献50

  • 1袁祖贻,刘艳,刘豫,张继军,岸本千晴,刘治全.PPARγ配体对小鼠急性心肌炎的影响及其机制[J].中华医学杂志,2003,83(23):2067-2072. 被引量：5
  • 2袁祖贻,刘艳,刘豫,张继军,岸本千晴,王燕妮,马爱群,刘治全.比格列酮和15d-PGJ_2抑制促炎细胞因子减轻自身免疫性心肌炎[J].中华心血管病杂志,2004,32(12):1104-1108. 被引量：1
  • 3陈永熙,王伟铭,周同,陈楠.PPAR-γ作用及其相关信号转导途径[J].细胞生物学杂志,2006,28(3):382-386. 被引量：82
  • 4章慧娣,王伟铭,陈楠.PPARγ与肾脏炎症调节研究进展[J].中国中西医结合肾病杂志,2007,8(5):299-301. 被引量：5
  • 5Chen PT, Mukherjee R, et al. PPARs as targets for metabolic and cardiovascular diseases[J]. Mini Rev Med Chem, 2005, 5(8): 741- 53.
  • 6Hongtao Wang, Jiming Jia, Siwen Tang, etc. Multi-objective Optimization Research for Effective Constituents of QiliQiangxin Capsule of Chinese formula, The 4th International Conference on Bioinformatics and Biomedical Engineering, June, 2010, Chengdu, China(In press).
  • 7Bradley Efron, Trevor Hastie, Iain Johnstone, et al. Leastangle regression[J]. The Annals of Statistics, 2004, 32(2) : 407-451.
  • 8Leichtweis S, Leeuwenburgh C, Bejma J, et al. Aged rat hearta are not more susceptible to ischem a-reperfusion injury in vivo role of glutathione[J]. MechAgeingDev, 2001, 122(6): 503-518.
  • 9Bianciardi P,Fantacci M,Caretti A,et al.Chronic in vi-vo hypoxia in various organs:hypoxia-inducible factor-1αand apoptosis[J].Biochem Biophys Res Commun,2006,342(3):875-880.
  • 10Kazuhiro Ito,Shimada,Kato D,et al.Protective effects of preischemic treatment w ith pioglitazone,a peroxisome proliferator-activated receptor ligand,on lung ischemia-reperfusion injury in rats[J].European Journal of Car-dio-Thoracic Surgery,2004,25(4):530-536.

引证文献4

二级引证文献37

中国病理生理杂志
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部