腮腺炎合并脑膜脑炎急性期脑脊液中IL-1、IL-6、IL-8、TNF-α的变化及其意义

Detection of IL-1, IL-6, IL-8 and TNF-α levels in CSF and Its clinical significance during acute stage in children with mumps complicated with meningoencephalitis

为探讨细胞因子在病毒性脑炎发病中的作用及意义,对30例腮腺炎合并脑膜脑炎患儿脑脊液测定了IL-1、IL-6、IL-8(白细胞介素-1、6、8),TNF-α(肿瘤坏死因子),结果发现急性期腮脑患儿脑脊液中上述细胞因子均较对照组明显增高(P<0.01),说明腮腺炎合并脑膜脑炎的发病与IL-1、IL-6、IL-8、TNF-α密切相关。

In order to explore the effect of various cytokines in the pathogenesis of viral encephalitis in children ,the detection of IL-1, IL-6, IL-8 and TNF-a levels in CSF were carried out in 30 cases of mumps complicated with meningoen-cephalitis in this study. As a result,the data obtained showed that all these 4 cytokines in CSF were found to be significantly higher than those in controlled group during acute stage of the disease (P<0. 01). Therefore, the authors suggest that the pathogenesis of meningoencephalitis resulting from mumps might be closely related to the change in IL-1, IL-6, IL-8 and TNF-a levels in CSF.