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FOXP3和GITR在口腔扁平苔藓及口腔鳞状细胞癌中的表达及意义 被引量：2

Expression and significance of FOXP3 and GITR in oral lichen planus and oral squamous cell carcinoma
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摘要 目的研究FOXP3、GITR在口腔扁平苔藓(OLP)和口腔鳞状细胞癌(OSCC)组织中的表达及其意义。方法采用免疫组化方法检测30例OLP组织、30例OSCC组织和15例口腔正常黏膜(NOM)组织中FOXP3、GITR的表达。结果NOM组FOXP3和GITR阴性表达;OLP组和OSCC组FOXP3和GITR表达分别较NOM组显著增加(P<0.01);OLP组和OSCC组之间FOXP3和GITR表达无显著性差异(P>0.05);FOXP3和GITR在OLP组和OSCC组中的表达存在正相关关系。结论在OLP的发生及发展成OSCC过程中,FOXP3和GITR均可能起着一定的作用。 Objective To investigate the expression of FOXP3,GITR in oral lichen planus（OLP） and oral squamous cell carcinoma（OSCC） and its significance.Methods The expression of FOXP3 and GITR in 30 OLP,30 OSCC and 15 normal oral mucosa（NOM） was detected by immunohistochemical methods.Results The expression of FOXP3 and GITR was negative in NOM.The expression of FOXP3 and GITR in both OLP and OSCC was significantly higher than that in NOM（P〈0.01）.No significant difference of FOXP3 and GITR staining was found between OLP and OSCC（P〉0.05）.The expression of FOXP3 and GITR in both OLP and OSCC showed a positive correlation.Conclusion It is indicated that FOXP3 and GITR may play a role in the pathogenesis of OLP and progression of OSCC.
作者 漆明 臧磊 刘丽 韩恩善 李国富
机构地区 宁夏医科大学附属医院口腔科 宁夏医科大学附属医院病理科
出处 《现代口腔医学杂志》 CAS CSCD 2010年第1期52-55,共4页 Journal of Modern Stomatology
基金 宁夏科技厅科技攻关计划(2002-020-04) 2008年宁夏高等教育研究项目
关键词 口腔扁平苔藓 口腔鳞状细胞癌 FOXP3 GITR Oral lichen planus （OLP） Oral squamous cell carcinoma（OSCC） FOXP3 GITR
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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共引文献4

同被引文献17

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现代口腔医学杂志
2010年 第1期

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