一氧化碳中毒时血浆纤维连接蛋白与丙二醛的变化及临床意义

CHANGES OF PLASMA FIBRONECTIN AND SERUM MALOYLEDIALDEHYDE IN PATIENTS WITH ACUTE CARBON MONOXIDE POISONING

目的:确定一氧化碳中毒病人血浆纤维连接蛋白和血清丙二醛的变化.方法:60例急性一氧化碳中毒(ACMP)病人按临床表现分为轻、中、重度组,检测每位患者来诊时血浆纤维连接蛋白(PFn),丙二醛(MDA)及碳氢血红蛋白(COHb)浓度.PFn采用速率散射比浊法,MDA采用硫代巴比妥酸法.结果:1.轻度组PFn与对照组相比未降低,中、重度组明显下降(P<0.5).2.MDA含量在轻、中度组升高不显著,在重度组显著高于对照组(P<0.05).3.PFn与MDA呈显著负相关,PFn和COHb呈负相关,而MDA与COHb无明显相关.结论:对既往健康的ACMP患者,动态监测PFn及MDA水平,可作为判断ACMP病情程度的参考指标.

Aim: To determine changes of plasma fibronectin and serum maloyledialdehyde in patients with acute CO poison-ing. methods: 60 patients with acute carbon monoxide poisoning were divided into three groups: mild 、moderate and serious groups. Plasma fibronectin (PFn) and Lipid Peroxide (LPO) were analysized in every patients before treatment. PFn was deter-mined by the rate scattering turbidity and LPO was measured by the thiobarbituric acid assay (TBA) . Results: 1. There was re-markable decrease of PFn in patients with moderate and serious illed which have a significant difference compared with the control. 2. High level of serum LPO were found in serious illed patients. 3 . Significant negative correlations were found between the PFn levels and serum LPO. Conclusion: These discoveries suggest: For acute carbon monoxide poisoning patients PFn and LPO lev-els may be helpful for evaluating the clinical symptoms.