正常高值血压患者高敏C反应蛋白与尿微量清蛋白的相关性

Association of High Sensitivity C-reaction Protein and Albuminuria with Prehypertension

目的观察正常高值血压患者血清高敏C反应蛋白(hs-CRP)与尿微量清蛋白(ALB)的水平,分析两者之间的相关性。方法选择正常高值血压患者110例,对照组为同期体检健康者87例,用ELISA法分别测定血清hs-CRP、ALB;空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、体重指数(BMI)。结果正常高值血压组血清hs-CRP、ALB水平显著高于对照组(P<0.05);且存在性别差异,男性显著高于女性(P<0.05)。hs-CRP与ALB呈正相关(P<0.01,r=0.47),TC、TG、BMI、FBG、LDL均与二者呈正相关(P<0.05)。结论正常高值血压患者血清hs-CRP、ALB水平明显升高,提示机体已存在炎症反应。TC、TG、BMI、FBG、LDL均是炎症反应的相关因素,雌激素可能对女性心血管系统有保护作用。

ObjectiveTo investigate the changes of serum high sensitivity C-reactive protein level （hs CRP）and albuminuria （ALB） level in patients with prehypertension and to investigate the relationship between hs CRP and ALB. MethodsTotal FBG,TC,TG,BMI and LDL were measured in 110 patients with prehypertension and 87 normal controls. Serum CRP and ALB concentration was measured by ELISA. ResultsSerum hs- CRP, urinary albumin concentration in patients with prehypertension was significantly high and had difference between male and female （P〈0.05）. hs-CRP and ALB had positive correlation with TC, TG, BMI, FBG and LDL （All P〈0.05） .ConclusionThe serum hs- CRP and ALB level increased obviously in the patient with prehypertension,which indicated that an inflammation reaction existed in body.The elevated levels of TC, TG, FBG, LDL and BMI all correlate with inflammation. Estrogen may have protective effects on the female cardiovascular system.