精神分裂症患者视觉P_(300)与临床特征及脑血流、眼球活动的相关研究

Correlation of visual P_(300) with clinical feature,search eye movement and regional cerebral blood flow in patients with schizophrenia

目的探讨精神分裂症患者脑功能异常的基础。方法对３９例精神分裂症患者的Ｐ３００与临床特征进行相关分析，并对其中８例混合型患者的Ｐ３００与探查性眼球活动及区域脑血流进行了相关分析。结果Ｐｚ点的Ｐ３００潜伏期与ＳＡＮＳ总分及情感平淡、思维贫乏、兴趣／社交缺乏呈显著正相关（ｒ分别＝０．７０、０．６９、０．６５、０．６６、０．５９，Ｐ均＜０．０１）；Ｐ３００幅度仅在Ｆｚ点与ＳＡＮＳ总分、情感平淡、思维贫乏、兴趣／社交缺乏呈显著负相关（ｒ分别＝－０．４５、－０．３３、－０．３８、－０．３８，Ｐ＜０．０５或０．０１）。Ｆｚ、Ｃｚ点的Ｐ３００幅度与探查性眼球活动的眼球凝视点数呈显著相关（ｒ分别＝－０．３７、０．６２，Ｐ均＜０．０５）；区域脑血流显示的缺损和稀疏区以额叶为主，与Ｐ３００幅度地形图的异常区基本符合。结论提示精神分裂症患者中存在额叶整合功能的异常。

Objective The aim of the study was to explore the basis of brain dysfunction in patients with schizophrenia. Methods 39 schizophrenia patients were studied with P300, and the correlation of P300 and clinical feature was analyzed. In the patients with mixed pattern of schizophrenia, search eye movement (SEM) and regional cerebral blood flow (rCBF) were measured and the correlation of P300 and SEM and rCBF were analyzed too. Results There was significant correlation between P300 latency at Pz, P300 amplitude at Fz and score of scale for assessment of negative symptoms (SANS). P300 amplitudes at Fz and Cz were significantly correlated to eye fixed number of SEM in the patients with mixed pattern. The abnormality of rCBF was mainly found in frontal zone, which was approximately consistent with abnormality of P300 amplitude map. Conclusion The results suggest that there is a congregation dysfunction in frontal zone, which may be correlated with the negative symptoms in patients with schizophrenia.