慢性乙型肝炎病毒感染患者焦虑、抑郁与C-erbB-2P185癌基因蛋白表达

Anxiety and depression and C-erbB-2 P185 oncogene protein expression in the patients with chronic HBV infection

目的探讨焦虑、抑郁不良情绪与慢性乙型肝炎发展和转归的关系。方法采用ＬＳＡＢ免疫组化和ＥＬＩＳＡ方法，检测５２例慢性乙型肝炎病毒感染者的肝细胞ＣｅｒｂＢ２Ｐ１８５癌基因蛋白及血清ＨＢｅＡｇ，同时进行焦虑自评量表（ＳＡＳ）和抑郁自评量表（ＳＤＳ）调查，并与国内常模对照。结果显示ＣｅｒｂＢ２Ｐ１８５癌基因蛋白阳性患者ＳＡＳ和ＳＤＳ总标准分均值升高，分别为４４±６和４９±１０，并差异有非常显著性，（Ｐ＜０．０１）。结论提示焦虑、抑郁情绪可能对慢性乙型肝炎的发生、发展起作用。

Objective This study explored the relationship between anxiety and depression and chronic hepatitis B. Methods The expression of the protein product CerbB2 P185 in hepatic tissue and HBeAg in the serum were detected using immunohistochmical techniques and ELISA, and the anxiety and depression symptoms were measured with SAS and SDS in 52 patients with chronic HBV infection. Results The mean scores of SAS and SDS were 44±6 and 49±10 in the patients with positive oncogene protein CerbB2 P185, respectively, and were significantly higher than normal in China. Conclusion This study suggests that anxiety and depression may play an important role in the occurrance and progress of chronic hepatitis B.