痛立消用于吸入麻醉苏醒期镇痛

OBSERVATION OF THE ANALGESIC EFFECT OF KETANOV IN REVIVAL PERIOD AFTER INHALATION ANESTHESIA

择期中、大型腹部手术病人，男２２例，女１８例，年龄３６～５９岁，体重５７～８２ｋｇ，随机分为两组。麻醉：安定，芬太尼，琥珀胆碱诱导，吸入氧气、氧化亚氮和安氟醚维持麻醉。在手术行关腹时分别给病人肌注痛立消６０ｍｇ（Ⅰ组ｎ＝２０）或安慰剂（生理盐水）２ｍｌ（Ⅱ组ｎ＝２０）。结果：在麻醉后苏醒期，两组病人的意识和自主呼吸恢复时间近似，Ⅰ组病人：镇痛有效率１００％，镇痛持续时间１２．３±６．１８ｈ，无肌颤痛。Ⅱ组：病人躁动，伤口疼痛，肌颤痛８例。两组呼吸频率和呼气末二氧化碳均存在显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。Ⅰ组苏醒期的心率和收缩压与术前比较无显著性改变（Ｐ＞０．０５），而Ⅱ组则存在显著性改变（Ｐ＜０．０１）。

Twenty two male and 18 female patients undergoing selective abdominal operation, aged between 36 and 59 and weights between 57 and 82 kg were randomly divided into two groups. Diazepam, fentynl and scolin were used for anesthesic induction and O 2, N 2O, enflurane for maintance. When the abdominal cavity was being closed ketanov 60mg (in the first group, n=20) or NS 2ml (in the second group, n=20), were injected i.m.. The results showed that the recover time of conscious and automatic breath were alike. However complete analgesia was found in 100 percent cases in group Ⅰ with 12.3±6.18h maintance without myalgia, Whereas uneasy, incision ache and myalgia were reported in 8 patients in group Ⅱ. Breath rate and P ET CO 2 showed significant difference between the two groups (P<0.01,P<0.05).Heart rate and systolic pressure of the revival period did not show significant changes comparing with that of the preoperative period (P>0.05) in group Ⅰ whereas significant changes existed in group Ⅱ (P<0.01).