慢性粒细胞白血病患者骨髓细胞中Cox-2与Bcl-2的表达

Expression of Cox-2 and Bcl-2 in Bone Marrow Cells of Chronic Myelocytic Leukemia Patients

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摘要目的探讨慢性粒细胞白血病(CML)患者骨髓细胞中Cox-2与Bcl-2的表达与意义。方法应用免疫组化SP法检测42例CML患者(CML组)和30例健康体检者(正常对照组)骨髓细胞中Cox-2与Bcl-2的表达。结果CML组患者骨髓细胞中Cox-2与Bcl-2的表达水平和积分明显高于正常对照组(P<0.05);骨髓细胞中Cox-2与Bcl-2的表达呈正相关(r=0.675,P<0.05)。结论Cox-2和Bcl-2可能与CML的发生、发展有一定的关系。 Objective To investigate the expressions of Cox-2 and Bcl-2 in bone marrow cells of chronic myelocytic leukemia patients.Methods The expressions of Cox-2 and Bc1-2 in bone marrow cells of 42 cases of chronic myelocytic leukemia and 30 cases of normal control were detected by immunohistochemical method.Results The positive rate and score of Cox-2 and Bcl-2 in chronic myelocytic leukemia group were significantly higher than those in normal control group（P〈0.05）,and there was positive correlation between Cox-2 and Bcl-2 expression in bone marrow cells （r=0.675,P〈0.05）.Conclusion The overexpressions of Cox-2 and Bcl-2 may be involve in the progression of chronic myelocytic leukemia.

作者李萍颜金花

机构地区南昌大学第三附属医院血液科

出处《江西医学院学报》 CAS 2009年第9期26-27,35,共3页 Acta Academiae Medicinae Jiangxi

关键词慢性粒细胞白血病 COX-2 BCL-2 chronic myelocytic leukemia Cox-2 Bcl-2

分类号 R733.72 [医药卫生—肿瘤]

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慢性粒细胞白血病患者骨髓细胞中Cox-2与Bcl-2的表达

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