血肌酐、胱抑素C、血红蛋白水平与慢性心力衰竭的临床关系

The Clinical Relationship between the Levels of Creatinine,Cystatin-C,Haemoglobin and Chronic Heart Failure

目的研究慢性心力衰竭(CHF)患者的血肌酐、胱抑素C和血红蛋白水平与心功能分级(NYHA分级)的关系。方法测定心功能Ⅰ-Ⅳ级共163例患者血清中肌酐、胱抑素C、血红蛋白水平以及左室射血分数(LVEF),并进行相关性分析。结果心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ级CHF患者之间的血肌酐、胱抑素C、血红蛋白相比差异有显著性(P<0.05或<0.001);血肌酐、胱抑素C随着心功能分级递增而递增,与LVEF呈负相关(r=-0.265,P<0.05;r=-0.468,P<0.001)。血红蛋白随心功能分级递增而递减,与LVEF呈正相关(r=0.372,P<0.01)。结论血肌酐、胱抑素C水平在严重CHF患者中较高,而血红蛋白则较低,均可独立判断CHF患者的预后。

Objective To study the relationship between the levels of creatinine,cystatin-C,haemoglobin in chronic heart failure and heart function classification.Methods Creatinine,cystatin-C,haemoglobin levels in serum and left ventricular ejection fraction of 163 cases of chronic heart failure had been detected,then used statistics method to correlation analysis.Results Compaired the creatinine,cystatin-C,haemoglobin levels of chronic heart failure in which from heart function Ⅰto Ⅳ grade,there had significant differences（P0.05 or P0.001）.Creatinine and cystatin-C levels increased follow heart failure progress,and had negative relationship with left ventricular ejection fraction（r=-0.265,P〈0.05;r=-0.468,P〈0.001）.haemoglobin level decreased follow heart failure progress,and had positive relationship with left ventricular ejection fraction（r=0.372,P〈0.01）.Conclusion The levels of creatinine and cystatin-C were higher in severe heart failure,when haemoglobin level was lower,these indicators could independently evaluating the prognosis of heart failure.