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半枝莲中野黄芩苷对乳腺癌MCF-7细胞增殖及侵袭能力的影响 被引量:20

The Effects of Scutellarin in Barbated Skullcup Herb on Galactophore Cancer MCF-7 Cell Proliferation and Invasion Potentia
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摘要 目的研究半枝莲中主要成分野黄芩苷对乳腺癌MCF-7细胞增殖及侵袭能力的影响。方法体外培养乳腺癌MCF-7细胞,采用MTT法观察野黄芩苷对乳腺癌MCF-7细胞增殖的抑制作用;采用Transwell体外侵袭转移模型检测野黄芩苷对乳腺癌MCF-7细胞侵袭能力的抑制作用。结果野黄芩苷在10~80μg/mL浓度范围有明显抑制乳腺癌MCF-7细胞增殖的作用;野黄芩苷可明显抑制乳腺癌MCF-7细胞的侵袭能力,且呈一定的量效应关系。结论野黄芩苷具有明显抑制体外培养乳腺癌MCF-7细胞增殖及侵袭的作用。 Objective To investigate the effects of the Scutellarin,the key component of Barbated Skullcup Herb,on galactophore cancer MCF-7 cell proliferation and invasion potentia.MethodsTo observe Scutellarin inhibiting galactophore cancer MCF-7 cell proliferation by MTT,and inhibiting cell invasion potentia by Transwell invade-transfer model in vitro.Results galactophore cancer MCF-7 cell proliferation is obviously inhibited by Scutellarin with the concentration ranging from 10 μg/mL to 80 μg /mL.And cell invasion potentia is significantly inhibited by Scutellarin,and it was a certain amount of effect relationship.Conclusions Scutellarin has manifest inhibition effects on galactophore cancer MCF-7 cell proliferation and invasion potentia in vitro.
出处 《江西医学院学报》 2009年第10期12-14,共3页 Acta Academiae Medicinae Jiangxi
基金 江西省卫生厅科技计划项目(20083141) 江西省卫生厅中医药科研项目(2008A090)
关键词 野黄芩苷 MCF-7细胞 增殖 侵袭能力 乳腺癌 半枝莲 Scutellarin MCF-7 proliferation invasion potentia galactophore cancer Barbated Skullcup Herb
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