TUR-BT术后吡柔比星与羟基喜树碱膀胱灌注的疗效比较

Efficiency Comparison of Intravesical Pirarubicin with Hydroxycamptothecin after Transurethral Resection of Bladder Tumor

目的寻找预防膀胱肿瘤复发的有效方法。方法对82例经尿道膀胱肿瘤电切除术(TUR-BT)治疗的膀胱肿瘤患者分别使用吡柔比星(THP组,n=48)与羟基喜树碱(HCPT组,n=34)进行膀胱灌注,并做随访和疗效比较。结果THP组术后复发率(10.42%)明显低于HCPT组(26.47%)(P<0.05);THP组不良反应发生率为14.58%,少于HCPT组(23.53%)(P<0.05)。结论吡柔比星与羟基喜树碱均可降低膀胱肿瘤术后复发的几率,其中以吡柔比星较为有效、安全。

Objective To explore the effective methods of preventing recurrence of bladder carcinoma.Methods 82 patients were treated with preventative urinary bladder irrigation chemotherapy after transurethral resection of bladder tumor（TUR-BT）,including pirarubicin （THP） in 48 cases （THP group） and hydroxycamptothecin （HCPT） in 34 cases （HCPT group）.Follow-up was performed to compare the efficiency difference between the two groups.Results The postoperative tumor recurrence rate of THP group was significantly lower than that of HCPT group （10.42% vs 26.47%,P0.05）.Furthermore THP group had fewer side effects than HCPT group（14.58% vs 23.53%,P0.05）.Conclusion Both THP and HCPT can reduce the postoperative recurrence rate of bladder tumor,of which THP is more effective and safer.