大理地区近10年葡萄胎流行病学回顾性调查

Retrospective Investigation on the Epidemiology of Hydatidiform Mole over the past 10 Years in Dali

目的:调查分析大理地区近10年的葡萄胎患病资料,探讨葡萄胎的发病相关影响因素,为该病预防提供依据。方法:收集大理州医院和大理学院附属医院1999年—2008年的葡萄胎病例资料,计算各年患病率及各年龄段患病人数和频率,采用病例对照研究,对23例葡萄胎患者及23例其它疾病的妇女或健康体检妇女对照进行Logistic回归分析。结果:1999年—2008年间葡萄胎患病率总体呈下降趋势,患病妇女主要集中在21～30岁。单因素分析显示:人工流产史、动物油、腊肉制品与葡萄胎发病呈正相关;经多因素分析调整后,动物油、腊肉制品与葡萄胎发病仍呈正相关。结论:大理地区葡萄胎患病率总体呈下降趋势,其发病可能与人工流产史、食用过多腊肉制品及动物油有关。

Objective： To investigate the relevant influencing factors of hydatidiform mole over the past 10 years in Dali for medical prevention by analyzing the data of patients with hydatidiform mole. Method： The data of patients with hydatidiform mole from 1999 to 2008 in Dali People＇s Hospital and the Affiliated Hospital of Dali University were collected and analyzed for the prevalence rate per year and case number per age-segment and its frequency by using the Logistic regression analysis of 23 cases and its control group in a case-control study. Result： The prevalence rate of hydatidiform mole during the past 10 years decreased, and the most of patients involved were women aged from 21 to 30. The one-way analysis showed that induced-abortion history, intake of animal oil and preserved ham products had positive relationship with the pathogenesis of hydatidiform mole, and multi-factor analysis demonstrated that the intake of animal oil and preserved ham products were positively correlated with the prevalence rate of hydatiform mole. Conclusion： The prevalence rate of hydatidiform mole in Dali region is reduced, and its pathogenesis is likely related to the factors of induced-abortion historv and excessive intake of preserved ham and animal oil.