炎症性肠病的基础和临床研究进展

Advances in Basic and Clinical Studies on Inflammatory Bowel Disease

炎症性肠病(IBD)包括溃疡性结肠炎和克罗恩病,是一种在遗传易感性人群中由免疫反应紊乱所致的慢性肠道炎症。以往认为我国IBD极为少见,但近20年来,随着人们生活方式的改变和诊断水平的提高,其发病率呈逐年上升的趋势。在第六届上海国际胃肠病学会议上,与会的国内外专家讨论了IBD近年的最新进展,包括发病机制、生物标志物、治疗、内镜监测、肠道菌群与肠道疾病等方面。本文就上述会议内容并结合当前该领域的最新进展作一介绍。

Inflammatory bowel disease （IBD）, including ulcerative colitis and Crohn＇s disease, is chronic inflammatory disorder caused by dysregulated immune responses in genetically predisposed individuals. Previously, the prevalence and incidence of IBD are thought to be low in China. However, there have been reports of a rising incidence of IBD in the past 20 years since the emergence of modernization of lifestyle and enhancement of diagnostic efficiency. At the 6th Shanghai International Conference of Gastroenterology, renowned experts at home and abroad were invited to discuss the recent progress in the field of IBD, including pathogenesis, biological biomarkers, treatment, endoscopic surveillance, intestinal microbial flora and intestinal diseases, etc. In this paper, we summarized the conference presentations and the latest development in this field.