CD_(44)V6,E-cadherin在食管鳞状细胞癌中表达及其意义

Significance of CD_(44)V6 and E-cadherin protein expression in esophageal carcinoma

目的:探讨食管鳞状细胞癌中CD44V6和E-cadher-in表达的意义.方法:采用免疫组织化学染色法(SP法)检测52例食管鳞癌组织中CD44V6和E-cadherin表达的表达情况,另选取15例癌旁正常组织为对照,并分析其与临床病理参数的关系.结果:CD44V6在正常食管组织和食管鳞癌原发灶中阳性表达率分别为0,73.08%,二者间差异有统计学意义(P<0.05).E-cadherin在正常食管组织和食管鳞癌原发灶中阳性表达率分别100.00%,42.31%,二者间差异有统计学意义(P<0.05).食管癌组织中CD44V6的高表达及E-cadherin的低表达与食管癌的临床分期、浸润深度、淋巴结转移均呈正相关(P<0.05).E-cadherin表达与肿瘤的分化程度有明显相关性(P<0.05),而CD44V6表达与肿瘤的分化程度无明显相关性.两者表达均与患者性别、年龄、病理分型无关.食管癌组织中CD44V6和E-cadherin的表达显著负相关(r=-0.446,P<0.05).结论:CD44V6和E-cadherin表达与食管癌浸润转移密切相关,CD44V6阳性和E-cadherin阴性者更具有侵袭性和转移性,提示预后差.联合检测CD44V6阳性和E-cadherin有助于判断食管鳞状细胞癌的预后.

AIM：To investigate the expression of CD44V6 and E-cadherin,and clinical significance in esophageal squamous cell carcinomas.METHODS：The expression of CD44V6 and E-cadherin were detected in 52 esophageal neoplasms specimens and 15 normal tissue specimens with SP immunohistochemical staining.RESULTS：The positive rates of CD44V6 in carcinomas was 73.08% and was significantly higher than that in the normal epithelial tissues（P0.05）.The positive rates of E-cadherin in carcinomas was 42.31% and was significantly lower than that in the normal epithelial tissues（P0.05）.The expression of CD44V6 and E-cadherin were closely correlated with the clinical stage,infiltration depth and lymph node metastasis（P0.05）,and not with gender,age and pathological classification.In addition,the expression of E-cadherin was closely correlated with histological grade.The expression of CD44V6 was negative relation to that of E-cadherin（r=-0.446,P0.05）.CONCLUSION：Expression of CD44V6 and E-cadherin protein was correlated with the potential of invasion and metastasis in esophageal squamous cell carcinomas.The combined detection of CD44V6 and E-cadherin protein may be valuable in predicting the prognosis of esophageal carcinoma.