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绝经期后妇女子宫内膜息肉中雌、孕激素受体表达特点及意义 被引量：3

Expression and significance of estrogen receptor and progesterone receptor in the endometrial polyps in postmenopausal women
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摘要 目的:通过研究绝经后妇女子宫内膜息肉雌激素受体(ER)和孕激素受体(PR)的表达探讨其可能的发生机制及临床意义.方法:运用免疫组织化学方法检测并行半定量分析,对70例诊断子宫内膜息肉的绝经后妇女的内膜息肉及其邻近内膜组织中ER,PR的表达,并选用20例正常绝经后妇女的子宫内膜组织作为对照.结果:子宫息肉组腺体和间质内PR呈低水平表达,并明显低于对照组(P<0.05),其余各组中ER的表达无明显差异.结论:绝经后妇女PR的异常表达在子宫内膜息肉的发生中起重要作用. AIM：To investigate the significance and possible mechanism of endometrial polyps（EP） in postmenopausal women by evaluating the expression and significance of estrogen receptor（EP） and progesterone receptor（PR）.METHODS：Seventy postmenopausal women with EP,who were performed with endometrial biopsy and removing polyps,and 20 postmenopausal women with normal endometrium（EM） were as control group.The expression of ER and PR were evaluated by immunohistochemical method using a semiquantitative analysis.RESULTS：Expression of PR in gland and stroma were significantly decreased in endometrial polyps（P0.05）.The difference in expressions of ER in all groups was not found.CONCLUSION：Our date suggests that abnormal expressions of PR may play a crucial role in the pathogenesis of the EP in postmenopausal women.
作者 张博 王建 张颖 曹引丽
机构地区 渭南市中心医院妇产科 第四军医大学西京医院妇产科 陕西省妇幼保健院
出处 《第四军医大学学报》 北大核心 2009年第24期3142-3143,共2页 Journal of the Fourth Military Medical University
关键词 子宫内膜 息肉 雌激素受体 孕激素受体 endomerium endometrial polyps estrogen receptor progesterone receptor
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献4

  • 1王云丽,黄向华,李晓冬.子宫内膜息肉病因学及易患因素研究进展[J].国际生殖健康／计划生育杂志,2008,27(6):370-374. 被引量：25
  • 2Taylor LJ, Jackson TL, Reid JG, et al. The differential expression of oestrogen receptors, progesterone receptors, bcl-2 and ki457 in endometrial polyps[J]. Br J Obstet Gynaecol, 2003,110(9) :794 -798.
  • 3Maia H Jr, Maltez A, Studart E, et al. Effect of Previous hormone replacement therapy on endometrial polyps during monopause [ J ]. Gynecol Endoerinol, 2004,111 ( 11 ) : 1242 - 1247.
  • 4Me Gurgan P, Taylorl J, Duffy SR, et al. An immunohistochemical comparison of endometrial polyps from postmenopausal women exposed and notexposed to HRT [J]. Maturitas, 2006, 53(2) :454 -461.

二级参考文献21

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共引文献24

同被引文献34

  • 1刘小春,冯力民.子宫内膜息肉的分子生物学研究进展[J].国外医学（妇产科学分册）,2005,32(2):87-90. 被引量：21
  • 2彭雪冰,夏恩兰.子宫内膜息肉中雌激素受体和孕激素受体的表达特点及意义[J].首都医科大学学报,2006,27(1):117-119. 被引量：29
  • 3伍翠屏,蔡莲莲,王宗敏,胡越.子宫内膜息肉雌孕激素受体及Bax Bcl-2的表达及意义[J].中国实用妇科与产科杂志,2006,22(7):543-544. 被引量：13
  • 4夏恩兰.妇科内镜学[M].郑州:河南科学技术出版社,2003.88-89.
  • 5Clark TJ,Khan KS,Gupta JK.Current practice for thetreatment of benign intrauterine polyps:a national ques-tionnaire survey of consultant gynaecologists in UK[J].Eur J Obstet Gynecol Reprod Biol,2002,103(1):65-67.
  • 6Mittal K,Schwartz L,Goswami S,et al.Estrogen andprogesterone receptor expression in endometrial polyps[J].Int J Gynecol Pathol,1996,15(4):345-348.
  • 7Taylor LJ,Jackson TL,Reid JG,et al.The differential ex-pression of oestrogen receptors,progesterone receptors,Bcl-2and Ki67in endometrial polyps[J].BJOG,2003,110(9):794-798.
  • 8Koshiyama M,Yoshida M,Takemura M,et al.Immuno-histochemical analysis of distribution of estrogen recep-tors and progesterone receptors in the postmenopausalendometrium[J].Acta Obstet Gynecol Scand,1996,75(8):702-706.
  • 9Sant'Ana de Almeida EC,Nogueira AA,Candido dosReis FJ,et al.Immunohistochemical expression of estro-gen and progesterone receptors in endometrial polypsand adjacent endometrium in postmenopausal women[J].Maturitas,2004,49(3):229-233.
  • 10de Carvalho S,Campaner AB,Lima SM,et al.Differenti-al expression of estrogen and progesterone receptors inendometrial polyps and adjacent endometrium in postm-enopausal women[J].Anal Quant Cytol Histol,2011,33(2):61-67.

二级引证文献20

第四军医大学学报
2009年 第24期

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