光学相干断层成像术及其在眼科中的应用

Optical Coherence Tomography and Its Application in Ophthalmology

光学相干断层成像术(OCT)是近几年始用于临床的新型影象诊断技术。与超声成像等技术不同,它利用光波在生物组织的传播特性并检测反射光的时程延迟,构成组织横断面图象,以观察其微细结构并进行定量分析,纵向分辨力可高达10μm,并具有非接触性、非侵害性等特点。在眼科,它不仅能够对眼前节的结构进行成像,还可以对视网膜各层次结构进行清晰的显像,为多种眼内疾病、特别是青光眼的早期诊断和研究提供了一种新的有效途径。眼科学报1998;14:116—120。

Optical coherence tomography (OCT) is a new imaging modality that provides cross -sectional tomographs of ocular structure in vivo. OCT system utilizes propagation of light through, and the time - of - flight delay of light reflected back from biological tissue to produce false - color images of microstructure. OCT has superior spatial resolution (10μm) than other optical imaging instruments, and maybe achieved at arbitrary penetration depth in transparent tissue with a noncontact, noninvasive measurement. Such features make OCT useful for the early diagnosis, differential diagnosis and more sensitive monitoring of a variety of ocular abnormalities including glaucoma, retinal and anterior eye diseases. Eye Science 1998:14 ; 116 - 120.