间充质干细胞的免疫调节作用研究进展

Immunomodulatory effect of mesenchymal stem cells

间充质干细胞(mesenchymal stem cell,MSCs)属于成体干细胞,其具有广阔的临床应用前景。近年来人们发现MSCs有较强的免疫调节能力,并成功的将其用于治疗移植物抗宿主病(graft versus host disease,GVHD)。据此推测MSCs对于其它慢性炎症性或者免疫相关性疾病可能同样具有治疗作用。本文将从MSCs对各类免疫细胞的作用、可能的机制、相关的动物实验以及临床研究等方面对MSCs的免疫调节作用研究进展作一综述。

Mesenchymal stem cells as a kind of adult stem cells have broad prospects for clinical application. Resently people found MSCs have strong properties of immunoregulation, and successfully applied it to treat GVHD. Accordingly, other chronic inflammatory or abnormal immunoreaction associated diseases may also response to MSCs. This article will focus on the immunoregulation properties of MSCs to various immunocells in vitro, the possible underlying mechanisms, in vivo animal tests and clinical trials.