AMPK及脂肪细胞因子调节胰岛素抵抗的研究进展

Progress in AMPK and Adipocytokine in Regulation of Insulin Resistance

腺苷酸激活蛋白激酶(AMP-activated Protein Kinase,AMPK)信号通路是调节细胞能量状态的中心环节,被称为"细胞能量调节器",在增加骨骼肌对葡萄糖的摄取、增强胰岛素(Insulins,Ins)敏感性、增加脂肪酸氧化以及调节基因转录等方面发挥重要作用。在整体水平,AMPK通过激素和脂肪细胞因子如瘦素、脂联素和抵抗素等调节能量的摄入和消耗。多种脂肪源性细胞因子表达异常与胰岛素抵抗(Insulin Resistance,IR)密切相关,而胰岛素抵抗又是Ⅱ型糖尿病发生的基础,并贯穿于Ⅱ型糖尿病发生发展的全过程。研究AMPK及脂肪细胞因子与胰岛素抵抗的关系,将为AMPK作为防治肥胖和Ⅱ型糖尿病提供新的药理学靶点。

Amp-activated Protein Kinase （AMPK） signal path is the centric cycle of regulating cell energy, it is called ＂cell energy regulator＂. It plays important roles in increasing uptake of glucose in skeletal muscle, enhancing the sensitivity of Insulins, promoting oxidation of fatty acid and regulating the gene transcription. In the whole level, AMPK can regulate the uptake and consume of energy by hormone and adipocytokines such as leptin,adiponectin and resistin. The abnormal express of adipocytokines is closely relative to the insulin resistance, meanwhile, insulin resistance is the basic development of type 2 diabetic mellitus（T2DM）, which can be gone through the whole development and progress of T2DM. The study of the relationships between AMPK and adipocytokines and insulin resistance can be provided new pharmacology targets of preventing adipositas and T2DM.