心理社会因素在糖尿病发生过程中的作用及机理研究 Ⅳ.Ⅱ型糖尿病发生的危险因素分析

The Contribution and Mechanism of Psychosocial Factors in the Onset of Diabetes Mellitus: Ⅳ. Risk Factor Analysis on the Onset of NIDDM

目的：分析影响人类Ⅱ型糖尿病发生的危险因素，比较心理社会因素及生物因素的影响程度。方法：对１３１名糖耐量低减和９１名糖耐量正常者平均追踪１８个月，对影响血糖变化和发生糖尿病的人群的社会心理因素及某些生理因素进行Ｌｏｇｉｓｔｉｃ回归分析和相关分析。结果：在对正常转糖耐量低减的回归分析中，年龄和体重指数的影响最大；但在正常和糖耐量低减转糖尿病的两个回归分析中，生活事件强度的贡献量均排在第１位。结论：心理社会因素在一定的生理条件下对糖尿病的发生起作用，其环节可能在糖耐量低减转糖尿病过程。

Objective: To determing the risk factors of the onset of Non-Insulin Dependence DiabetesMellitus (NIDDM) with Logisitic regression analysis. Methods: A total 131 Imparing Glucose Tolerance(IGT) and 91 control subjects with normal glucose tolerance were followed by evaluation of their psychosocial factors and some physical indexs for 18 months. Results: Stress Life Events (SLE) is the first risk factor in two logistic regression analyses about blood glucose transformation from normal to NIDDM and from IGT to NIDDM, even though the contribution of SLE, active coping style and use of social support are less than that of age and Body Magnitude Index (BMI) in logistic regression analysis about blood glucose transformation from normal to IGT. Conclusion: Psychosocial factors show their roles based on the physical situations to onset of NIDDM and may mainly effect the process of blood transformation from IGT to NIDDM.