甲哨唑三种给药方案治疗高脂血症的随机对照研究

Observation on the Therapeutic Effect of Metronidazole in Different Regimens on Hyperlipemia

70例高脂血症病人采用三种口服甲硝唑给药方案治疗:(Ⅰ)0.6gtid×10d,n=10;(Ⅱ)0.4gtid×10d,n=20;(Ⅲ)0.2gtid×10d,n=40.三种方案甘油三酯下降总有效率为80.0%,65.0%及52.5%;胆固醇下降总有效率为80.0%,75.0%及57.5%.三种方案治疗后甘油三酯和胆固醇下降百分数为;甘油三酯为56.64%,38.7%及33.55%;胆固醇为34.56%,24.6%及21.81%.甲硝唑降甘油三酯和胆固醇作用快速、明显;甲硝唑剂量越大的方案,服药后不良反应越重.

Seventy patients with hyperlipemia were treated by oral metronidazole in 3 regimens: 1) 0.6 g tid for 10 days(n = 10); 2) 0.4 g tid for 10 days(n = 20), and 0.2 g tid for 10 day(n = 40). The total curative rates of the 3 in terms of reduction of triglycerin levels were 80.0%, 65.0% and 52.5% and the rates in terms of cholesterol level reduction were 80.0%, 75.0% and 57 . 5 % . The percentages of serum lipid reduction of the 3 regimens were 56. 64% ,38. 7% and 33.5% for triglycerin and they were 34. 56% , 24. 62% and 21.81 % for cholesterol. The serum lipids reducing effect of metronidazole was fast and obvious. More serious adverse drug reactions were found in large dose regimens group.