重型肝炎并发医院内真菌感染相关因素分析

Study on relative factors of severe hepatitis complicated by nosocomial fungal infection

目的了解重型肝炎(简称重肝)患者并发医院真菌感染的相关因素。方法对1996年6月～2006年6月该院收治的重肝患者中发生医院内真菌感染的病例进行回顾性分析。结果168例重肝并发真菌感染患者平均年龄(45±11)岁。其中,男126例,女42例,其感染因素为使用广谱抗生素和糖皮质激素、白细胞减少、疾病严重程度、侵袭性诊疗操作,是重型肝炎并发真菌感染的密切相关因素(P<0.01)。结论重肝并发真菌感染的相关因素和影响预后的因素对其预防、诊断、治疗、改善预后和提高生存质量有重要临床意义。

【Objective】To study relative factors of severe hepatitis complicated by fungal infection.【Methods】 The clinical data of 168 patients with severe hepatitis complicated by fungal infection from Jun 1996 to Jun 2006 was analyzed retrospectively. 【Results】For 168 patients with severe hepatitis complicated by fungal infection, the mean age was （45±11） years old, 126 patients were male and 42 ones were female. Susceptible factors were used of broad spectrum antibiotics and adrenal cortex hormones, leucopenia, degree of severe hepatitis and invasive procedures, they are intimate relative factors of severe hepatitis complicated by nosocomial fungal infection （P 〈0.01）. [ ConcLusion] The relative factors and factors of influencing prognosis of severe hepatitis eomplicated by fungal infection have important signifieanees for prevention, diagnosis, treatment, improving prognosis and existence quality.