结直肠癌术中腹腔植入缓释氟尿嘧啶的临床研究

Clinical study of intraperitoneal interstitial implant with sustained release fluorouracil during operation for advanced colorectal cancer

目的探讨进展期结直肠癌术中腹腔植入缓释氟尿嘧啶的安全性及疗效。方法60例行结直肠癌根治术患者,分为术中植入缓释氟尿嘧啶组(治疗组)和对照组,治疗组在瘤床和沿淋巴回流区域分多点植入缓释氟尿嘧啶,观察2组术后伤口愈合情况,有无吻合口瘘、肠梗阻、腹膜炎、腹腔复发和肝转移等。结果治疗组与对照组术后出现吻合口瘘、肠梗阻、腹膜炎以及肠功能恢复时间差异均无显著性(P>0.05)。术后随访3年,治疗组腹腔复发和肝转移率较对照组低(P<0.05)。结论结直肠癌术中腹腔植入缓释氟尿嘧啶是安全的,具有良好的耐受性,是预防术后复发转移的有效途径。

【Objective】To explore the safety and effective way to prevent the local recurrence of advanced colorectal cancer after operation. 【Methods】60 patients with advanced colorectal cancer were randomly divided into control group and sustained-release fluorouracil group. The tumor was surgically removed and sustained-release fluorouracil was implanted multiple point during operation in the tumor cavity to observe the incidence of wound infection, anastomosis leakage, intestinal obstruction and peritonitis.[ Results ] The difference of side effects and postoperative complications between control group and sustained-release fluorouracil group was not obviously. The local recurrence and metastasis rate between controlled group and sustained-release fluorouracil group was obviously. [ Conclusions ] The way of intraperitoneal interstitialimplant with sustained-release fluorouracil during operation for advanced coloreetal cancer is safe, and it might become a new effective method to prevent postoperative local recur rence of colorectal cancer.