急性胆源性胰腺炎愈后胰腺功能变化

Analysis of pancreatic function after recovery from acute biliary pancreatitis

目的研究急性胆源性胰腺炎(ABP)患者愈后胰腺内、外分泌系统的功能变化。方法随访58例ABP患者,其中重型ABP(SABP)20例,轻型ABP(MABP)38例,分别采用放射免疫分析法和酶联免疫法测定血中CP和FE1水平,同时测定36例健康人作为对照。结果SABP患者CP值低于MABP患者及健康者,差异有显著性(均P<0.05)。MABP患者CP值与健康者比较差异无显著性(P>0.05)。SABP患者和MABP患者FE1值均较健康者降低(均P<0.05),SABP患者降低更明显(P<0.05)。结论ABP患者愈后胰腺外分泌功能受到破坏,血中FE1水平降低;SABP患者愈后胰岛内分泌细胞功能也受到破坏,而MABP患者愈后胰岛内分泌细胞功能无明显变化。

【Objective】To investigate the pancreatic function of endocrine secretory system and exocrine secretory system after recovery from acute biliary pancreatitis （ABP）.【Methods】The levels of CP and FE1 in 58 patients after recovery from ABP including severe acute biliary pancreatitis （SABP） 20 cases and mild acute biliary pancreatitis （MABP） 38 cases, and in 36 healthy controls were tested by radio immunoassay method and ELISA method respectively. 【Results】The levels of CP in patients after recovery from SABP were lower than those in patients after recovery from MABP and in healthy controls, there were statistical significance （P 〈0.05）. There were no statistical significance between MABP and healthy controls （P 〉0.05）. The levels of FE1 in patients after recovery from acute pancreatitis were lower than those in healthy controls （P 〈0.05）. [ Conclusions] The pancreatic exocrine secretory system is damaged in patients after recovery from acute biliary pancreatitis. The levels of FE1 were lower. The pancreatic function of endocrine secretory system is lower in patients after recovery from SABP. The pancreatic function of endocrine secretory system is normal in patients after recovery from MABP.