参麦注射液雾化吸入防治急性放射性肺炎的临床效果

Clinnical value of prevention and treatment of acute radiation-induced pneumonitis by inhalation of senmai injection

目的探讨参麦注射液雾化吸入在防治急性放射性肺炎中的作用。方法将2007年8月～2008年7月在该院治疗的局部晚期非小细胞肺癌患者60例,随机分成治疗组与对照组各30例,治疗组给予参麦注射液雾化吸入加同期化、放疗,对照组给予同期化、放疗,两组放疗方式及化疗方案相同。观察两组患者急性放射性肺炎开始出现的时间及反应程度。结果实验组患者开始出现放射性肺炎的时间明显晚于对照组,差异有显著性;实验组患者出现放射性肺炎的程度明显轻于对照组,差异有显著性。结论参麦注射液雾化吸入防治急性放射性肺炎疗效显著,使用方便,值得临床推广应用。

【Objective】To explore the clinical value of prevention and treatment of acute radiation-induced pneumonitis by inhalation of Senmai injection.【Methods】 Sixty patients with local advaced non-small-cell lung cancer from August 2007 through July 2008 in our hospital were assigned randomly into two groups： thirty patients in the treatment arm received inhalation of Senmai injection and concurrent chemoradiotherapy; thirty patients in the control arm received concurrent chemoradiotherapy.Two arms received the same chemoradiotherapy. The time acute radiation-induced pneumonitis occurred and sevevity of acute radiation-induced pneumonitis were observed and analysed. [Results] The time acute radiation-induced pneumonitis occurred in the treatment arm is later than in the control arm ; sevevity of acute radiation-induced pneumonitis in the treatment ann were smaller than in the control arm, the difference is significant statistically. [ Conclusion ] Inhalation of senmai injection is a useful and convinent way in the prevention and treatment of acute radiation-induced pneumonitis.