左旋氨氯地平(施慧达)治疗老年支气管哮喘临床研究

Clinical study of Levamlodipine Tablets(SHI HUI DA) in treatment of senilel bronchia asthma

目的观察钙离子拮抗剂左旋氨氯地平(施慧达)对老年支气管哮喘(简称哮喘)患者的支气管平滑肌的影响。方法选择伴有原发性高血压病或血压在120～135/60～85mmHg的中度急性发作期老年哮喘患者31例(年龄>60岁)。随机分成常规治疗组(A组,15例),和左旋氨氯地平联合治疗组(B组,16例)。观察治疗1周后的临床疗效。结果左旋氨氯地平联合治疗组治愈率明显高于常规治疗组(χ2=4.40,P<0.05)有显著性差异。结论在常规治疗哮喘的基础上加用左旋氨氯地平可以取得更好的疗效。实验证明,左旋氨氯地平作为一种阻断血管平滑肌细胞钙内流、舒张血管、降低血压的药物,还能有效地阻滞支气管平滑肌细胞的钙内流,抑制平滑肌兴奋-收缩耦联,舒张支气管,控制哮喘。这也是该药治疗哮喘的基本理论依据。

【Objective】To observe the effects of the calcium antagonist in elderly patients with bronchial asthma bronchial smooth muscle, namely Levamlodipine Tablets （SHI HUI DA）.【Methods】Associated with primary hypertension or blood pressure in the 120～135/60～85 mmHg moderate acute exacerbation of asthma in patients aged 32 cases （age 60 years old） were randomly divided into conventional therapy group （A group of 16 patients） and Levam-lodipine conbination therapy group （B group of 16 patients）. Then observing the treatment and clinical efficacy after one week. [Results] Levamlodipine combination therapy group cure rate was significantly higher than the conventionl therapy group （P 〈0.05）. There was a significant difference in it. [ Conclusions ] In the conventional treatment of asthma based on the Levamlodipine Besylate Tablets were added to obtain a greater efficacy. Experiments show that Levamlodipine recognized as a vascular smooth muscle cells, blocking calcium influx, diastolic blood vessels, lower blood pressure drugs, hut also effectively block bronchial smooth muscle ceils, calcium influx, inhibit smooth muscle exeitement-cantraction coupling and relaxation bronchus, control asthma. This is also the basic theory of drug treatment of asthma based on.