肉毒素A治疗女性膀胱过度活动症的临床对比研究

Clinical contrast studies of Botulinum Toxin-A in the treatment of overactive bladder in female

目的探讨女性膀胱过度活动症的治疗方法。方法选择2005年1月～2007年6月期间,安阳市人民医院确诊为女性膀胱过度活动症的患者,采用随机方法分为A组和B组。A组将100IU的肉毒素A稀释于20mL生理盐水,使用膀胱镜注射针分20个点注射于膀胱壁,1mL/点;B组患者口服酒石酸托特罗定片,每天口服2次,每次2mg,疗程连续服用6～8周;治疗前后均记录患者I-PSS评分、初尿意膀胱容量、最大膀胱容量。结果50例患者随访时间6个月,治疗后IPSS评分下降,初尿意膀胱容量及最大膀胱容量上升,治疗后和治疗前相比,具有显著性差异(P<0.05)。结论经尿道膀胱壁内肉毒素A注射和口服酒石酸托特罗定均是治疗女性膀胱过度活动症的有效方法,肉毒素A注射更有效,但因其有创,尤其适合于口服酒石酸托特罗定无效者或二线用药。

【Objective】To approach treatment ways of female bladder overwork.【Methods】During Jan 2005 and Jun 2007, 50 female patients with overactive bladder in the People s Hospital of Anyang were chosen and randomly assigned to group A and group B. A patients group were injected creation-A 20 spots in their wall of urinary bladder, 1 mL/spot by bladder spectacle. 100 IU creation-A was diluted in 20 mL physiologic saline. B patients group were asked to take orally tartaric acid Tolterodine stator twice everyday, 2 mg every time, eontinuouing 6-8 weeks. It was requested to record patients＇ I-PSS, initial micturition desire bladdler capacity, maximum bladder capacity as pre-therapy or post-therapy. [ Results ] The 50 eases were followed up for 6 months. Patients＇ IPSS went down, but their initial micturition desire Bladder Capacity and their maximum bladder capacity was improved. Post-therapy and pretherapy phase ratio, their results were significant diferenee （P 〈0.05）. [ Conehlsions ] Through urethra to wall of urinary bladder to inject creatoxin-A or to take orally tartaric acid Tolterodine were modus operandi to heal female bladder overwork. But creatoxin-A was better. Because of its found it is especial to fit for nonresponder who took orally tartaric acid Tolterodine or dicho-clue medication.