血吸虫性肝纤维化患者胰岛素样生长因子-1与肝功能间的关系

The relationship between serum insulin-like growth factor-1 and liver function in patients with schistosomal liver fibrosis

目的研究血吸虫性肝纤维化患者血清胰岛素样生长因子-1(IGF-1)与肝功能之间的关系。方法收集50例诊断明确的血吸虫性肝纤维化患者临床资料,以30名体检的健康人作为对照,分别测定血清IGF-1、肝功能、肝纤维化等指标。结果血吸虫性肝纤维化组的IGF-1高于健康对照组(P<0.05)。血吸虫性肝纤维化组的IGF-1浓度在不同肝功能Child-pugh分级中差异有统计学意义,Child-pugh分级越差,IGF-1浓度越高。在所有80例被检者中IGF-1与总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)、天门冬氨酸氨基转移酶(AST)呈正相关(r=0.554、0.570、0.479、0.016,P<0.05),与血清总蛋白(TP)、白蛋白(Alb)呈负相关(r=-0.257、-0.531,P<0.05)。IGF-1与透明质酸(HA)、Ⅳ型胶原(C-Ⅳ)、Ⅲ型胶原(C-Ⅲ)呈正相关(r=0.580、0.655、0.542,P<0.05)。结论血吸虫性肝纤维化患者血清IGF-1增加与肝功能减退、肝纤维化程度相一致,可能与血吸虫性肝纤维化的发生、发展有关。

Objective To study the relationship between serum insulin-like growth factor-1 （ICF-1） and liver function in patients with schistosomal liver fibrosis. Methods The clinical data of 80 cases （50 cases diagnosed with schistosomiasis and 30 cases from health examination as controls） were collected. The 1GF-1 level, liver function and liver fibrosis indexes were detected. Results The IGF-1 level was higher in patients with schistosomiasis than in the controls（ P 〈 0.05 ）. The IGF-1 level in patients with schistosomiasis was correlated with liver function Child-pugh classification. The IGF-1 level was positively correlated with the levels of total bilirubin（ TBil）, direct bilirubin（ DBil）, indirect bilirubin （IBil） and aspartate aminotransferase （AST） （ r = 0. 554, 0. 570, 0. 479,0. Ol 6, P 〈 0.05 ） , and was negatively correlated with the levels of serum total protein （TP） and albumin （Alb） （ r = - 0. 257, - 0. 531, P 〈 0.05 ）. The IGF-1 level was also positively correlated with hyaluronic acid （HA）, type Ⅳ collagen （C-Ⅳ） and type m collagen （C-Ⅲ） （r = 0. 580, 0. 655, 0. 542, P 〈 0. 05 ）. Conclusions The serum IGF-1 level increases in patients with schistosomiasis, and this level increases with hypohepatia and the progression of liver fibrosis. The IGF-1 might be involved in the pathogenesis of liver fibrosis.