胱抑素C在糖尿病早期肾损害诊断中的临床意义

Clinical significance of cystatin C in the diagnosis of early renal damage in diabetes mellitus

目的评价血清胱抑素C在糖尿病患者肾损伤早期发生中的作用及意义。方法应用全自动生化分析仪采用免疫比浊法测定40例糖尿病患者和40例的血清Cys-C、BUN、Cr的浓度,并把糖尿病组与对照组的结果进行比较。结果糖尿病组的检测结果为Cys-C(1.41±0.67)mg/L、BUN(6.24±3.74)mmol/L、Cr(79.25±55.07)μmol/L,而正常对照组为Cys-C(0.92±0.21)mg/L、BUN(4.89±4.36)mmol/L、Cr(74.05±90.92)μmol/L。糖尿病组中Cys-C、BUN和Cr阳性数分别为18例(45.0%)、6例(15.0%)、4例(10.0%)。糖尿病组较正常对照组的检测结果明显增高,差异有统计学意义(P<0.01)。结论糖尿病患者血清中Cys-C有明显改变,Cys-C在反映糖尿病肾损害方面比Cr、BUN优越,值得在临床上推广应用。

Objective To study the early diagnostic value of serum cystatin C for the patients with diabetes mellitus.Methods The serum Cys - C, Scr and BUN level were measured and comparatived in 40 patients who had steady - state diabetes with early renal impairments and 40 health controls patients , according to the detecting of RILI 7060. Results The resuits of the patients with diabetes rnellitus were Cys - C （1.41± 0. 67 ）, BUN （6. 24 ± 3.74）, Cr（ 79.25 ± 55.07 ）, the results of health controls were Cys - C（0.92 ±0. 21 ） ,BUN（4. 89 ±4. 36） ,Cr（74.05±90. 92） ,The serum Cys - C level in patients with period diabetes mellitus was significantly higher than that in health controls, the masculine rates of Cys - C, BUN and Cr in patients who had steady- state diabetes with early renal impairment were 18 （0.45）, 6 （0. 15 ） , 4 （0. 10 ）. Conclusion Serum Cystatln C has inportant diagnostic value for the patients with diabetes mellitus.