慢性阻塞性肺病急性加重患者血脂代谢特点及与肺组织炎症关系的研究

The correlation between lipid metabolism and inflammatory of lung in patients with chronic obstructive pulmonary disease

目的本研究旨在探讨慢性阻塞性肺病急性加重患者血脂特点及与肺组织炎症的关系。方法对42例慢性阻塞性肺病患者,进行甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、肺功能及体重指数(BMI)的测定,依第1秒用力呼气容积(FEV1)分组进行分析探讨。结果 FEV1<30%预计值组HDL-c明显高于FEV1>30%预计值组(P<0.05)。FEV1<30%预计值组的女性亚组较FEV1>30%预计值组的女性亚组HDL-c亦增高(P<0.05),男性患者HDL-c两组变化不明显。TG、TC、LDL-c各组间比较差异无统计学意义。结论慢性阻塞性肺病急性加重患者血脂代谢与肺组织炎症反应及性别有关,可反映慢性阻塞性肺病总体病情的严重程度,长期吸入沙美特罗氟替卡松(舒利迭)可能对改善脂代谢有益。

Objective To evaluate the correlation between lipid metabolism and inflammatory of lung in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods Serum triglyceride （ TG）, total cholesterol （ TC ）, high density lipopretein - cholesterol（ HDL - c ）, low density lipoprotein - cholesterol （ LDL - c ）, pulmonary function and body mass index （BMI） were measured in 42 COPD patients, who were enrolled in this exiperiment. All subjects were divided into two groups by FEV1 （ FEV1 〉 30% pred group and FEV1 〈 30% pred group）. Results The mean values of HDL - c in FEV1 〈 30% pred group were higher than that in FEV1 〉 30% pred group（ P 〈 0. 05 ）. The results in female subgroup come to the same. The mean values of HDL - c in each male subgroup were no difference. The mean values of TG, TC, LDL - c In each group were also no difference. Conclusion There is correlation between lipid metabolism and inflammatory of lung in patients with AECOPD. It can reflect the severity of COPD. It is probablely beneficial to improving lipid metabolism that patients with COPD inhale salmeterol/fluticasone propionate （seretide） chronically.