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CpG寡脱氧核苷酸在支气管哮喘免疫治疗中的潜在意义

The Potential Significance of CpG-ODN Immunotherapy in Bronchial Asthma
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摘要 支气管哮喘是由多种炎性细胞参与的呼吸道慢性炎性疾病,发病机制较为复杂,Th1/Th2比例失衡在支气管哮喘的发病中起着重要作用。寡脱氧核苷酸(CpG-ODN)作为非特异性免疫调节剂,可以使Th1表达上调,从而纠正Th1/Th2比例失衡。CpG-ODN不仅能够有效地抑制过敏性哮喘呼吸道炎症的发展,而且能够逆转这种已建立的炎症,因此,CpG-ODN可能成为治疗过敏性哮喘的一种新手段。 Asthma is a kind of inflammatory diseases involving many kinds of inflammation cells in airways. The pathogenesis is complex,and the imbalance of Th1/Th2 plays an important role in asthma. As a non-specific immunomodulator,CpG-ODN increases the expression of Th1, to correct the imbalance between Th1/Th2. CpG-ODN prevents the development of atopic airways disease,and promotes the reversal of established eosinophilic inflammation. CpG-ODN may become a novel therapeutic tool in treating atopic asthma.
作者 贾明雅 吴斌
机构地区 广东医学院附属医院呼吸病研究所
出处 《医学综述》 2010年第2期241-244,共4页 Medical Recapitulate
关键词 脱氧寡核苷酸 支气管哮喘 免疫调节 Oligodeoxynucleotide Bronchial asthma Immunoregulation
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献22

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医学综述
2010年 第2期

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