重庆市妇女乳腺癌危险因素的病理对照研究

A Case Control Study of Risk Factors for Breast Cancer in Chongqing Women

[目的]研究女性乳腺癌的危险因素。[方法]在重庆市进行了首次1：1流行病学病例对用研究。[结果]多因素条件Logistic回归分析显示了下列因素对乳腺癌的影响：女性初期年龄（OR＝0．79.95％CI＝0.67-0．92），月经紊乱史（OR＝1.47，95％CI＝1．07-2.02），高龄初产（OR＝1．55，95％CI＝1．20-1.98），乳腺良性疾病史（OR＝2．33，95％CI＝1．02-5.33），肿瘤家族史（OR＝1．61，95％CI＝1．27-2．08），长期生活精神刺激因素（OR＝2．55，95％CI＝1.19-5．44）和被动吸烟史（OR＝2.22，95％CI＝1.37-3.59）.[结论]女性初潮年龄与乳腺癌发生应呈负相关，而月经紊乱，高龄初产，乳腺良性疾病史，肿瘤家族史，长期生活精神刺激因素和被动吸烟是乳腺癌的高危因素。

[Purpose ] To investigate the risk factors for breast cancer.[Method] A case control study was conducted in Chongqing;[Results] Affter adjustment for a wide range of covariates,miltivanrlate conditional logistic analysis indicated that: age at early menarche(Odds ratio(OR) = 0.79: OR 95% confident in terval (CI) =0.67 -0.92); menstrual disorder (OR =1 .47,CI = 1 .07 - 2.02): old age at first childbirth (OR= 1 .55,CI= 1 .20 - 1 .98),history of benign breast sisease (OR = 2.33,CI= 1.02 - 5.33), farnily history of cancer (OR= 1.61, CI= 1.27 - 2.08), experiences of serious lifetime stress (OR = 2.55,CI= 1. 19 - 5.44) and passive smoking (OR= 2.22,CI = 1.37 - 3.59). [Conclusion]Age at early merarche was negatively associated with breast cancer .While menstrual disorder, old age at first childbirth,history of benigh breast disease,family history of cancer,expericences of serious lifetime stress and passive smoking were high risk factors for breast cancer.