动脉自旋标记技术(ASL)在一侧大脑中动脉狭窄或闭塞中脑组织灌注信息的研究

ASL for evaluation of unilateral middle cerebral artery stenosis or occlusion in brian tissue perfusion imaging

目的探讨动脉自旋标记技术(ASL)对大脑中动脉狭窄或闭塞灌注信息的诊断价值,为指导临床治疗提供依据。方法回顾性分析36例TIA患者及5例健康志愿者,对比弥散成像(DWI)与灌注成像即动态磁敏感对比增强(DSC)和动脉自旋标记技术(ASL)显示病灶大小的情况,得到平均通过时间(MTT),达峰时间(TTP),脑血容量(CBV),脑血流量(CBF)图,分析DSC和ASL结果的差异。结果DSC检查患侧与健侧灌注程度改变,T=2.91,α水平设在0.05,P<0.01,有统计学意义。ASL检查患侧与健侧灌注程度的改变,T=2.37,α水平设在0.05,P<0.05,具有统计学意义。对比DSC及ASL方法显示患侧灌注程度,卡方值为-0.984,P>0.05为无统计学差别。结论用ASL完全无创性的方法,对灌注程度进行定量的分析,且实行方便、操作简单,这种灌注成像对缺血性脑血管病的诊断价值得以肯定。

Objective To disscuss diagnostic value of ASL in the middle cerebral artery stenosis or occlusion reperfusion, in order to provide a guide for clinical treatment. Methods This study collected a total of 36 cases of TIA patients and 5 healthy volunteers, DWI, DSC and ASL showing the size of lesions were compared. The perfusion difference between ASL and DSC through the MTT, TTP, CBV, CBF map was compared. Results DSC was examined through the perfusion abnormality of unilateral and contralateral perfusion change, T = 2.91, P 〈 0.01, with statistical significance. ASL showed the perfusion abnormality of unilateral and contralateral changes in perfusion, T = 2.37, P 〈 0.05, with statistical signifi- cance. Comparison of DSC and ASL per＇fusion method showed no difference （ chi - square value of - 0. 984, P 〉 0.05 ）. Conclusion ASL,need no contrast injection of invasive operation, is convenient and useful method in assessing cerebral perfusion information of ischemic cerebrovascular disease.